5-(1H-Indol-3-yl)oxazole

Base Information

• Chemical Name: 5-(1H-Indol-3-yl)oxazole
• CAS No.: 120191-50-6
• Molecular Formula: C11H8N2O
• Molecular Weight: 184.197
• ChEMBL ID: CHEMBL2252885
• DSSTox Substance ID: DTXSID60479298
• Nikkaji Number: J2.140.647C
• Wikidata: Q82313286
• Mol file: 120191-50-6.mol

Synonyms:5-(3-indolyl)oxazole

Chemical Property of 5-(1H-Indol-3-yl)oxazole

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 184.063662883
• Heavy Atom Count: 14
• Complexity: 210

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=CN2)C3=CN=CO3

Technology Process of 5-(1H-Indol-3-yl)oxazole

There total 1 articles about 5-(1H-Indol-3-yl)oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-(4-tolylsulfonyl)indole-3-carboxaldehyde (50562-79-3) + [(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) → 5-(1'-tosyl-3'-indolyl)oxazole + 5-(1H-indol-3-yl)oxazole (120191-50-6)

Guidance literature:

With potassium carbonate; In methanol; for 2h; Heating;

DOI:10.1016/j.tet.2004.12.022

Reference yield: 72.0%

5-(1H-indol-3-yl)oxazole (120191-50-6) → streptochlorin (120191-51-7)

Guidance literature:

With N-chloro-succinimide; In tetrahydrofuran; tetrachloromethane; at 50 ℃; for 8h;

DOI:10.1016/j.ejmech.2012.04.012

Reference yield: 69.0%

benzenesulfonyl chloride (98-09-9) + 5-(1H-indol-3-yl)oxazole (120191-50-6) → 5-(1-(phenylsulfonyl)-1H-indol-3-yl)oxazole (1383483-13-3)

Guidance literature:

5-(1H-indol-3-yl)oxazole; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; Cooling with ice;

benzenesulfonyl chloride; In tetrahydrofuran; mineral oil; at 20 ℃;

DOI:10.1016/j.ejmech.2012.04.012

upstream raw materials:

1-(4-tolylsulfonyl)indole-3-carboxaldehyde

[(p-methylphenyl)sulfonylmethyl]isonitrile

Downstream raw materials:

N-[2-(1H-indol-3-yl)-2-oxoethyl]-2-phenylacetamide

34N

pimprinine

pimprinethine