4-Amino-6-chloropyridazin-3(2H)-one

Base Information

• Chemical Name: 4-Amino-6-chloropyridazin-3(2H)-one
• CAS No.: 14704-64-4
• Molecular Formula: C₄H₄ClN₃O
• Molecular Weight: 145.548
• European Community (EC) Number: 816-349-4
• DSSTox Substance ID: DTXSID601293701
• Mol file: 14704-64-4.mol

Synonyms:4-Amino-6-chloropyridazin-3(2H)-one;14704-64-4;4-amino-6-chloro-3(2H)-Pyridazinone;4-amino-6-chloro-2,3-dihydropyridazin-3-one;5-amino-3-chloro-1H-pyridazin-6-one;MFCD11109440;3(2H)-Pyridazinone, 4-amino-6-chloro-;SCHEMBL1393609;DTXSID601293701;ZB0117;5-amino-3-chloropyridazin-6(1h)-one;AKOS006306906;SY143801;CS-0135326;EN300-122788;W19056;A902498

Chemical Property of 4-Amino-6-chloropyridazin-3(2H)-one

Chemical Property:

• Density: 1.79g/cm³
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 145.0042895
• Heavy Atom Count: 9
• Complexity: 208

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=O)NN=C1Cl)N

Technology Process of 4-Amino-6-chloropyridazin-3(2H)-one

There total 2 articles about 4-Amino-6-chloropyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

6-chloro-2H-pyridazin-3-one (19064-67-6) → 5-Amino-3-chloropyridazin-6(1H)-one (14704-64-4) + 5-amino-6-chloro-3(2H)-pyridazinone (17285-22-2) + 4-amino-6-hydrazino-3(2H)-pyridazinone hydrochloride

Guidance literature:

With hydrazine hydrate; for 0.5h; Heating;

Reference yield:

4-amino-6-chloro-3-methoxypyridazine (14369-14-3) → 5-Amino-3-chloropyridazin-6(1H)-one (14704-64-4) + 5-amino-6-methoxy-3(2H)-pyridazinone (14369-21-2)

Guidance literature:

With potassium hydroxide; potassium acetate; acetic acid; Yield given. Multistep reaction; 1.) 150-155 deg C, 4 h, 2.) reflux, 40 min;

Reference yield:

5-Amino-3-chloropyridazin-6(1H)-one (14704-64-4) + benzoyl chloride (98-88-4) → 6-chloro-2-phenyl-oxazolo[5,4-c]pyridazine (111163-93-0)

Guidance literature:

upstream raw materials:

6-chloro-2H-pyridazin-3-one

4-amino-6-chloro-3-methoxypyridazine

Downstream raw materials:

6-chloro-2-phenyl-oxazolo[5,4-c]pyridazine