3-Methyl-benzo[d]isoxazole-5-boronic acid pinacol ester

Base Information

Chemical Name:3-Methyl-benzo[d]isoxazole-5-boronic acid pinacol ester
CAS No.:1314136-00-9
Molecular Formula:C14H18BNO3
Molecular Weight:259.113
Hs Code.:
Mol file:1314136-00-9.mol

Synonyms:3-Methyl-benzo[d]isoxazole-5-boronic acid pinacol ester;3-Hydroxy-2,3-dimethylbutan-2-yl hydrogen (3-methylbenzo[d]isoxazol-5-yl)boronate;3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]isoxazole

Suppliers and Price of 3-Methyl-benzo[d]isoxazole-5-boronic acid pinacol ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3-Methyl-Benzo[D]Isoxazole-5-BoronicAcidPinacolEster
50mg
$ 175.00

Crysdot
3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]isoxazole 95+%
1g
$ 608.00

Chemenu
3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]isoxazole 96%
1g
$ 602.00

Total 4 raw suppliers

Chemical Property of 3-Methyl-benzo[d]isoxazole-5-boronic acid pinacol ester

Chemical Property:

PSA：44.49000
LogP:2.43540

Purity/Quality:

97% ^*data from raw suppliers

3-Methyl-Benzo[D]Isoxazole-5-BoronicAcidPinacolEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Methyl-benzo[d]isoxazole-5-boronic acid pinacol ester

There total 4 articles about 3-Methyl-benzo[d]isoxazole-5-boronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 66033-76-9
5-bromo-3-methyl-1,2-benzisoxazole

: 73183-34-3
bis(pinacol)diborane

: 1314136-00-9
3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzisoxazole

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 80 ℃; for 15h; Inert atmosphere;
DOI:10.1021/jacs.7b03131

Reference yield:

: 1450-75-5
5-Bromo-2-hydroxyacetophenone

: 1314136-00-9
3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzisoxazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; potassium acetate / ethanol / 16 h / Reflux

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone; triphenylphosphine / dichloromethane / 0.42 h / 20 °C

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / Inert atmosphere; Reflux

With hydroxylamine hydrochloride; potassium acetate; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 1416157-63-5
(E)-1-(5-bromo-2-hydroxyphenyl)ethanone oxime

: 1314136-00-9
3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; triphenylphosphine / dichloromethane / 0.42 h / 20 °C

2: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / Inert atmosphere; Reflux

With potassium acetate; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; dichloromethane;