66033-76-9

Basic information

• Product Name: 1,2-BENZISOXAZOLE, 5-BROMO-3-METHYL-
• Synonyms: 1,2-BENZISOXAZOLE, 5-BROMO-3-METHYL-;5-BroMo-3-Methylbenzo[d]isoxazole;5-BroMo-3-Methyl-1,2-benzoxazole
• CAS NO: 66033-76-9
• Molecular Formula: C₈H₆BrNO
• Molecular Weight: 212.04334
• Mol File: 66033-76-9.mol
• Article Data: 10

Chemical Properties

• Melting Point: 43 °C(Solv: ethanol (64-17-5))
• Boiling Point: 292.5±20.0 °C(Predicted)
• Appearance: /
• Density: 1.606±0.06 g/cm3(Predicted)
• PKA: -2.59±0.30(Predicted)
• CAS DataBase Reference: 1,2-BENZISOXAZOLE, 5-BROMO-3-METHYL-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-BENZISOXAZOLE, 5-BROMO-3-METHYL-(66033-76-9)
• EPA Substance Registry System: 1,2-BENZISOXAZOLE, 5-BROMO-3-METHYL-(66033-76-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 66033-76-9(Hazardous Substances Data)

Usage

General Description

1,2-Benzisoxazole, 5-bromo-3-methyl- is a chemical compound with the molecular formula C9H7BrON. It is a substituted benzisoxazole derivative, which is a heterocyclic compound containing both a benzene ring and an oxazole ring. This chemical is used as a building block in organic synthesis and has potential applications in pharmaceutical research and drug development. It is known for its unique chemical structure, which gives it specific reactivity and properties that make it valuable in various scientific and industrial applications. Additionally, it is important to note that 1,2-Benzisoxazole, 5-bromo-3-methyl- should be handled and used with proper safety precautions due to its potential hazards and risks.

Upstream product

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• 1416157-63-5 (E)-1-(5-bromo-2-hydroxyphenyl)ethanone oxime 

Downstream Products

• 478169-74-3 3-methylbenzo[d]isoxazole-5-carboxylic acid 
• 1314136-00-9 3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzisoxazole 

Relevant articles and documents

ISOXAZOLINE DERIVATIVES AND THEIR USES IN AGRICULTURE RELATED APPLICATION

The present invention provides isoxazoline derivatives and uses thereof in agriculture; in particular, the present invention provides a compound having formula (I), or a stereoisomer, an N-oxide or a salt thereof, preparation methods thereof, and compositions containing these compounds and uses thereof in agriculture, particularly uses as herbicide active ingredients for controlling unwanted plants; wherein R1, R2, R3, R4, n, R5, R6 and Hy are as described in the invention.

Derisking the Cu-Mediated 18F-Fluorination of Heterocyclic Positron Emission Tomography Radioligands

Molecules labeled with fluorine-18 (18F) are used in positron emission tomography to visualize, characterize and measure biological processes in the body. Despite recent advances in the incorporation of 18F onto arenes, the development of general and efficient approaches to label radioligands necessary for drug discovery programs remains a significant task. This full account describes a derisking approach toward the radiosynthesis of heterocyclic positron emission tomography (PET) radioligands using the copper-mediated 18F-fluorination of aryl boron reagents with 18F-fluoride as a model reaction. This approach is based on a study examining how the presence of heterocycles commonly used in drug development affects the efficiency of 18F-fluorination for a representative aryl boron reagent, and on the labeling of more than 50 (hetero)aryl boronic esters. This set of data allows for the application of this derisking strategy to the successful radiosynthesis of seven structurally complex pharmaceutically relevant heterocycle-containing molecules.

BENZOISOXAZOLE-SUBSTITUTED COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION

Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.