17,21-dihydroxy-20-oxo-5β-pregnan-3α-yl β-D-Glucopyranosiduronic Acid

Base Information

Chemical Name:17,21-dihydroxy-20-oxo-5β-pregnan-3α-yl β-D-Glucopyranosiduronic Acid
CAS No.:56162-40-4
Molecular Formula:C27H42O10
Molecular Weight:526.624
Hs Code.:
Mol file:56162-40-4.mol

Synonyms:(3α,5β)-17,21-Dihydroxy-20-oxopregnan-3-yl β-D-Glucopyranosiduronic Acid;17,21-dihydroxy-20-oxo-5β-pregnan-3α-yl β-D-Glucopyranosiduronic Acid;Tetrahydro-11-deoxy Cortisol 3-O-β-D-Glucuronide

Suppliers and Price of 17,21-dihydroxy-20-oxo-5β-pregnan-3α-yl β-D-Glucopyranosiduronic Acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Tetrahydro-11-deoxyCortisol3-O-β-D-Glucuronide
50mg
$ 1320.00

Medical Isotopes, Inc.
Tetrahydro-11-deoxyCortisol3-O-β-D-Glucuronide
50 mg
$ 2200.00

Total 5 raw suppliers

Chemical Property of 17,21-dihydroxy-20-oxo-5β-pregnan-3α-yl β-D-Glucopyranosiduronic Acid

Chemical Property:

PSA：173.98000
LogP:0.59900

Purity/Quality:

99% ^*data from raw suppliers

Tetrahydro-11-deoxyCortisol3-O-β-D-Glucuronide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses The 3-monoglucuronide conjugate of Tetrahydro-11-deoxycortisol (T293390).

Technology Process of 17,21-dihydroxy-20-oxo-5β-pregnan-3α-yl β-D-Glucopyranosiduronic Acid

There total 5 articles about 17,21-dihydroxy-20-oxo-5β-pregnan-3α-yl β-D-Glucopyranosiduronic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 640-87-9
cortexolone 21-acetate

: 56162-40-4
17,21-dihydroxy-20-oxo-5β-pregnan-3α-yl β-D-glucopyranosiduronic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 3.5 g / hydrogen, palladium-on-calcium carbonate / pyridine / 8 h / 760 Torr

2: 1.5 g / hydrogen, Raney Ni (W-2) / dioxane / 8 h

3: 330 mg / AgCO₃ / toluene / 12 h / Ambient temperature

4: NaHCO₃ / methanol; H₂O; CHCl₃ / 48 h / Ambient temperature

5: 1.) NaOH; 2.) 80percent pyruvic acid, AcOH / 1.) MeOH/CHCl₃, rt., 2 h; 2.) CHCl₃, rt., 12 h

With sodium hydroxide; silver (II) carbonate; Lindlar's catalyst; Raney Ni (W-2); hydrogen; sodium hydrogencarbonate; acetic acid; 2-oxo-propionic acid; In 1,4-dioxane; pyridine; methanol; chloroform; water; toluene;
DOI:10.1248/cpb.31.4001

Reference yield:

: 16065-01-3
21-acetoxy-3α,17α-dihydroxy-5β-pregnan-20-one

: 56162-40-4
17,21-dihydroxy-20-oxo-5β-pregnan-3α-yl β-D-glucopyranosiduronic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 330 mg / AgCO₃ / toluene / 12 h / Ambient temperature

2: NaHCO₃ / methanol; H₂O; CHCl₃ / 48 h / Ambient temperature

3: 1.) NaOH; 2.) 80percent pyruvic acid, AcOH / 1.) MeOH/CHCl₃, rt., 2 h; 2.) CHCl₃, rt., 12 h

With sodium hydroxide; silver (II) carbonate; sodium hydrogencarbonate; acetic acid; 2-oxo-propionic acid; In methanol; chloroform; water; toluene;
DOI:10.1248/cpb.31.4001

Reference yield:

: 26439-43-0
5β-dihydro-11-deoxycortisol 21-acetate

: 56162-40-4
17,21-dihydroxy-20-oxo-5β-pregnan-3α-yl β-D-glucopyranosiduronic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1.5 g / hydrogen, Raney Ni (W-2) / dioxane / 8 h

2: 330 mg / AgCO₃ / toluene / 12 h / Ambient temperature

3: NaHCO₃ / methanol; H₂O; CHCl₃ / 48 h / Ambient temperature

4: 1.) NaOH; 2.) 80percent pyruvic acid, AcOH / 1.) MeOH/CHCl₃, rt., 2 h; 2.) CHCl₃, rt., 12 h

With sodium hydroxide; silver (II) carbonate; Raney Ni (W-2); hydrogen; sodium hydrogencarbonate; acetic acid; 2-oxo-propionic acid; In 1,4-dioxane; methanol; chloroform; water; toluene;
DOI:10.1248/cpb.31.4001