26439-43-0

Basic information

• Product Name: 17-hydroxy-3,20-dioxopregnan-21-yl acetate
• CAS NO: 26439-43-0
• Molecular Formula: C₂₃H₃₄O₅
• Molecular Weight: 390.5131
• Mol File: 26439-43-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 519.5°C at 760 mmHg
• Flash Point: 173.4°C
• Density: 1.169g/cm³
• Vapor Pressure: 5.78E-13mmHg at 25°C
• Refractive Index: 1.533
• CAS DataBase Reference: 17-hydroxy-3,20-dioxopregnan-21-yl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 17-hydroxy-3,20-dioxopregnan-21-yl acetate(26439-43-0)
• EPA Substance Registry System: 17-hydroxy-3,20-dioxopregnan-21-yl acetate(26439-43-0)

Safety Data

• Hazardous Substances Data: 26439-43-0(Hazardous Substances Data)

Usage

Type of medication

Synthetic progestin

Uses

Treatment of preterm labor, menstrual disorders, and hormone replacement therapy

Mechanism of action

Binds to and activates progesterone receptors in the body

Regulation

Regulates the menstrual cycle and maintains pregnancy

Forms available

Oral tablets, injections, and vaginal suppositories

Potential side effects

Nausea, breast tenderness, and changes in menstrual bleeding patterns

Upstream product

• 64-17-5 ethanol 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 95006-63-6 21-bromo-17-hydroxy-5β-pregnane-3,20-dione 
• 640-87-9 cortexolone 21-acetate 
• 570-58-1 5β-17α-hydroxy-preganene-3,20-dione 

Downstream Products

• 640-87-9 cortexolone 21-acetate 
• 601-03-6 3β,5β-Tetrahydro Reichstein's Substance S 
• 56162-40-4 17,21-dihydroxy-20-oxo-5β-pregnan-3α-yl β-D-glucopyranosiduronic acid 
• 68-60-0 tetrahydrodeoxycortisol 
• 566-42-7 5β-pregnan-17α,21-diol-3,20-dione 

Relevant articles and documents

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Potential corticoid metabolites: Chemical synthesis of 3- and 21-monosulfates and their double-conjugates of tetrahydrocorticosteroids in the 5 α- and 5 β-series

Here, we describe the chemical synthesis of the complete sets of 18 novel 3- and 21-monosulfates and their double-conjugated form of tetrahydrocortisol (THF), tetrahydro-11-deoxycortisol (THS), and tetrahydrocortisone (THE) in the 5 α- and 5 β-series. The principal reactions involved are: (1) selective protection of a specific hydroxy group in substrates; (2) catalytic hydrogenation at C-5 of Δ4-3-ketosteroids with 10% Pd(OH) 2/C to yield 3-oxo-5 β-steroids and reductive allomerization with 10% Pd/C to yield 3-oxo-5 α-isomers; (3) reduction of the resulting 3-oxo-5 β- and 3-oxo-5 α-steroids to the corresponding 3 α-hydroxy-compounds with Zn(BH4)2 and K-Selectride, respectively; and (4) sulfation of hydroxy groups at C-3 and/or C-21 in the tetrahydrocorticosteroid derivatives with sulfur trioxide-triethylamine complex.

Preparation of haptens for use in immunoassays of tetrahydro-11-deoxycortisol and its glucuronides.

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