5-Bromo-2H-indazole

Base Information

• Chemical Name: 5-Bromo-2H-indazole
• CAS No.: 465529-55-9
• Molecular Formula: C₇H₅BrN₂
• Molecular Weight: 197.034
• Mol file: 465529-55-9.mol

Synonyms:5-Bromo-2H-indazole

Chemical Property of 5-Bromo-2H-indazole

Chemical Property:

• PSA: 28.68000
• LogP: 2.32540

Purity/Quality:

95%+ ^*data from raw suppliers

5-Bromo-2H-indazole ＞95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Bromo-2H-indazole

There total 1 articles about 5-Bromo-2H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.21%

5-bromo-2-fluorobenzaldehyde (93777-26-5) → 5-bromo-2H-indazole (465529-55-9,53857-57-1)

Guidance literature:

With hydrazine hydrate; In water; at 110 ℃; for 16h;

Reference yield: 88.0%

5-bromo-2H-indazole (465529-55-9,53857-57-1) + trans-2-(3-benzyloxiran-2-yl)ethan-1-ol → (3S*,4R*)-(±)-3-(5-bromo-2H-indazol-2-yl)-5-phenylpentane-1,4-diol

Guidance literature:

With 4-fluorophenylboronic anhydride; at 75 ℃; for 16h; regioselective reaction; Sealed tube;

DOI:10.1021/acs.orglett.1c02412

Reference yield: 72.0%

5-bromo-2H-indazole (465529-55-9,53857-57-1) + bis(pinacol)diborane (73183-34-3) → 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-indazole (1423792-82-8,862723-42-0)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 130 ℃; for 12h; Inert atmosphere;

upstream raw materials:

5-bromo-2-fluorobenzaldehyde

Downstream raw materials:

2H-indazole-5-carbaldehyde

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2H-indazole

2-Methyl-5-bromo-2H-indazole

Refernces

• 1、 -. "SUBSTITUTED 2-HYDROGEN-PYRAZOLE DERIVATIVE SERVING AS ANTICANCER DRUG". Paragraph 0081; 0082; 0083. . Retrieved 2018/02/04.