2,6-DIFLUORO-4-IODOPHENOL

Base Information

• Chemical Name: 2,6-DIFLUORO-4-IODOPHENOL
• CAS No.: 950858-06-7
• Molecular Formula: C6H3F2IO
• Molecular Weight: 255.99
• Hs Code.: 2908199090
• Mol file: 950858-06-7.mol

Synonyms:2,6-DIFLUORO-4-IODOPHENOL

Chemical Property of 2,6-DIFLUORO-4-IODOPHENOL

Chemical Property:

• Vapor Pressure: 0.144mmHg at 25°C
• Melting Point: 70-73℃
• Boiling Point: 208.932°C at 760 mmHg
• Flash Point: 80.16°C
• PSA: 20.23000
• Density: 2.163g/cm³
• LogP: 2.27500
• Sensitive.: Light Sensitive
• Water Solubility.: Insoluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,6-Difluoro-4-iodophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-DIFLUORO-4-IODOPHENOL

There total 1 articles about 2,6-DIFLUORO-4-IODOPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2,6-difluorophenol (28177-48-2) → 2,6-difluoro-4-iodophenol (950858-06-7)

Guidance literature:

With iodine; potassium iodide; sodium hydroxide; In water; at 0 - 20 ℃;

DOI:10.1002/ejoc.201000161

Reference yield: 71.0%

2,6-difluoro-4-iodophenol (950858-06-7) + C11H11F3OS2 → 7-fluoro-5-iodo-2-(methylsulfanyl)-3-[4-(trifluoromethyl)phenyl]benzofuran

Guidance literature:

2,6-difluoro-4-iodophenol; C₁₁H₁₁F₃OS₂; With trifluoroacetic anhydride; In acetonitrile; at -20 ℃; for 2h; Schlenk technique; Inert atmosphere;

With zinc; In acetonitrile; at -20 - 20 ℃; for 1h; Schlenk technique; Inert atmosphere;

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/anie.201809035

Reference yield:

2,6-difluoro-4-iodophenol (950858-06-7) + 2-(methylsulfinyl)benzo[b]thiophene → C15H9F2IOS2

Guidance literature:

With trifluoroacetic anhydride; In acetonitrile; at -40 ℃; for 0.25h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c01904

upstream raw materials:

2,6-difluorophenol

Downstream raw materials:

2,6-difluoro-4-iodoanisole

Refernces

• 1、 Francke, Robert,Schnakenburg, Gregor,Waldvogel, Siegfried R.. "Efficient and reliable iodination and o-Methylation of fluorinated phenols". experimental part. p. 2357 - 2362. Retrieved 2010/07/04.