4-amino-N-[2-(morpholin-4-yl)ethyl]benzamide

Base Information

• Chemical Name: 4-amino-N-[2-(morpholin-4-yl)ethyl]benzamide
• CAS No.: 51-09-2
• Molecular Formula: C13H18N2
• Molecular Weight: 249.313
• European Community (EC) Number: 844-791-8
• Mol file: 51-09-2.mol

Synonyms:4-amino-N-[2-(morpholin-4-yl)ethyl]benzamide;51-09-2;4-amino-N-(2-morpholin-4-ylethyl)benzamide;4-amino-N-(2-morpholinoethyl)benzamide;SCHEMBL3543817;OBTQKZSCIDELLN-UHFFFAOYSA-N;AKOS000137914;MCULE-1027150216;DB-295213;CS-0251731;EN300-55908;G21218;Z240087956

Chemical Property of 4-amino-N-[2-(morpholin-4-yl)ethyl]benzamide

Chemical Property:

• Boiling Point: 486.7±40.0 °C(Predicted)
• PSA: 67.59000
• Density: 1.169±0.06 g/cm3(Predicted)
• LogP: 1.24080
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 249.147726857
• Heavy Atom Count: 18
• Complexity: 259

Purity/Quality:

97% ^*data from raw suppliers

4-Amino-N-[2-(morpholin-4-yl)ethyl]benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1CCNC(=O)C2=CC=C(C=C2)N

Technology Process of 4-amino-N-[2-(morpholin-4-yl)ethyl]benzamide

There total 8 articles about 4-amino-N-[2-(morpholin-4-yl)ethyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(2-morpholinoethyl)-4-nitrobenzamide (3948-64-9) → 4-amino-N-[2-(morpholin-4-yl)ethyl]benzamide (51-09-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; under 22502.3 Torr;

Reference yield: 35.0%

4-(2-AMINOETHYL)MORPHOLINE (2038-03-1) + 4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → 4-amino-N-[2-(morpholin-4-yl)ethyl]benzamide (51-09-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 - 30 ℃; for 2h; Inert atmosphere;

Reference yield: 26.0%

4-(2-AMINOETHYL)MORPHOLINE (2038-03-1) + 4-(N-tert-butoxycarbonyl)aminobenzoic acid (66493-39-8) → 4-amino-N-[2-(morpholin-4-yl)ethyl]benzamide (51-09-2)

Guidance literature:

4-(2-AMINOETHYL)MORPHOLINE; 4-(N-tert-butoxycarbonyl)aminobenzoic acid; With benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; for 72h;

In dichloromethane; N,N-dimethyl-formamide; for 72h;

With trifluoroacetic acid; at 20 ℃; for 168h;

upstream raw materials:

4-(2-AMINOETHYL)MORPHOLINE

p-aminoethylbenzoate

N-(2-morpholinoethyl)-4-nitrobenzamide

4-nitro-benzoyl chloride

Downstream raw materials:

4-[2-hydroxy-2-(4-trifluoromethylphenyl)acetylamino]-N-(2-morpholin-4-ylethyl)benzamide

C₂₄H₃₄N₄O₃

C₂₀H₂₃ClN₄O₃

C₂₀H₂₄N₄O₃