tert-butyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate
CAS No.:1415991-88-6
Molecular Formula:C₂₄H₂₇FN₂O₅S
Molecular Weight:474.553
Hs Code.:

Synonyms:tert-butyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate

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Technology Process of tert-butyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate

There total 5 articles about tert-butyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415991-87-5
tert-butyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}-5,6-dihydropyridine-1(2H)-carboxylate

: 1415991-88-6
tert-butyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 14h; under 2844.39 Torr;

Reference yield:

: 142994-04-5
2-fluoro-4-(methylsulphonyl)benzoic acid

: 1415991-88-6
tert-butyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: polyposphoric acid / 3.5 h / 195 °C

1.2: pH 9

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 105 °C / Inert atmosphere

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere; Microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 2844.39 Torr

With hydrogen; potassium acetate; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; 3.1: Suzuki Coupling;

Reference yield:

: 40925-68-6
2-amino-4-bromo-phenol

: 1415991-88-6
tert-butyl 4-{2-[2-fluoro-4-(methylsulfonyl)phenyl]benzo[d]oxazol-5-yl}piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: polyposphoric acid / 3.5 h / 195 °C

1.2: pH 9

2.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 12 h / 105 °C / Inert atmosphere

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide / 1.5 h / 80 °C / Inert atmosphere; Microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / methanol / 14 h / 2844.39 Torr

With hydrogen; potassium acetate; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; 3.1: Suzuki Coupling;