t-butyl 4-[3-(methylthio)phenyl]-4-(2-oxoethyl)piperidine-1-carboxylate

Base Information

Chemical Name:t-butyl 4-[3-(methylthio)phenyl]-4-(2-oxoethyl)piperidine-1-carboxylate
CAS No.:716359-86-3
Molecular Formula:C₁₉H₂₇NO₃S
Molecular Weight:349.494
Hs Code.:

Synonyms:t-butyl 4-[3-(methylthio)phenyl]-4-(2-oxoethyl)piperidine-1-carboxylate

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Chemical Property of t-butyl 4-[3-(methylthio)phenyl]-4-(2-oxoethyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of t-butyl 4-[3-(methylthio)phenyl]-4-(2-oxoethyl)piperidine-1-carboxylate

There total 5 articles about t-butyl 4-[3-(methylthio)phenyl]-4-(2-oxoethyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.5%

: 716360-12-2
C₁₉H₂₆N₂O₂S

: 716359-86-3
t-butyl 4-[3-(methylthio)phenyl]-4-(2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: C₁₉H₂₆N₂O₂S; With diisobutylaluminium hydride; In dichloromethane; at -35 ℃; for 0.5h; Inert atmosphere;

With methanol; In dichloromethane; at -35 ℃;
DOI:10.1021/jm200279v

Reference yield:

: 193537-11-0
tert-butyl 4-(1-cyano-2-ethoxy-2-oxoethylidene)-4-piperidine-1-carboxylate

: 716359-86-3
t-butyl 4-[3-(methylthio)phenyl]-4-(2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide / tetrahydrofuran / 2 h / Inert atmosphere

2.1: water; sodium hydroxide / 2 h / 20 °C

3.1: copper(I) oxide / acetonitrile / 0.5 h / Inert atmosphere; Reflux

4.1: diisobutylaluminium hydride / dichloromethane / 0.5 h / -35 °C / Inert atmosphere

4.2: -35 °C

With copper(I) oxide; copper(l) iodide; water; diisobutylaluminium hydride; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm200279v

Reference yield:

: 716360-11-1
C₂₀H₂₆N₂O₄S

: 716359-86-3
t-butyl 4-[3-(methylthio)phenyl]-4-(2-oxoethyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(I) oxide / acetonitrile / 0.5 h / Inert atmosphere; Reflux

2.1: diisobutylaluminium hydride / dichloromethane / 0.5 h / -35 °C / Inert atmosphere

2.2: -35 °C

With copper(I) oxide; diisobutylaluminium hydride; In dichloromethane; acetonitrile;
DOI:10.1021/jm200279v