ethyl (R)-3-(tert-butyldimethylsilyloxy)-4-((2R,6S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)butanoate

Base Information

Chemical Name:ethyl (R)-3-(tert-butyldimethylsilyloxy)-4-((2R,6S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)butanoate
CAS No.:1028481-67-5
Molecular Formula:C₄₆H₆₈O₇Si₂
Molecular Weight:789.213
Hs Code.:

ethyl (R)-3-(tert-butyldimethylsilyloxy)-4-((2R,6S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)butanoate

Synonyms:ethyl (R)-3-(tert-butyldimethylsilyloxy)-4-((2R,6S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)butanoate

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Chemical Property of ethyl (R)-3-(tert-butyldimethylsilyloxy)-4-((2R,6S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)butanoate

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Technology Process of ethyl (R)-3-(tert-butyldimethylsilyloxy)-4-((2R,6S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)butanoate

There total 6 articles about ethyl (R)-3-(tert-butyldimethylsilyloxy)-4-((2R,6S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 854749-31-8
(4S,6S)-8-(tert-Butyl-diphenyl-silanyloxy)-6-(4-methoxy-benzyloxy)-2-trimethylsilanylmethyl-oct-1-en-4-ol

: 1028481-45-9
ethyl (R)-3-(tert-butyldimethylsilyloxy)-5-oxopentanoate

: 1028481-67-5
ethyl (R)-3-(tert-butyldimethylsilyloxy)-4-((2R,6S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)butanoate

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In diethyl ether; at -78 ℃; for 1h;
DOI:10.1021/ja8022169

Reference yield:

: 365404-48-4
5-benzyloxy-3-(tert-butyl-dimethyl-silanyloxy)-pentanoic acid ethyl ester

: 1028481-67-5
ethyl (R)-3-(tert-butyldimethylsilyloxy)-4-((2R,6S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 48 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 1 h / -5 °C

3: trimethylsilyl trifluoromethanesulfonate / diethyl ether / 1 h / -78 °C

With trimethylsilyl trifluoromethanesulfonate; palladium 10% on activated carbon; hydrogen; sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: C₁₃H₂₈O₄Si

: 1028481-67-5
ethyl (R)-3-(tert-butyldimethylsilyloxy)-4-((2R,6S)-6-((S)-4-(tert-butyldiphenylsilyloxy)-2-(4-methoxybenzyloxy)butyl)-4-methylenetetrahydro-2H-pyran-2-yl)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 1 h / -5 °C

2: trimethylsilyl trifluoromethanesulfonate / diethyl ether / 1 h / -78 °C

With trimethylsilyl trifluoromethanesulfonate; sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; dimethyl sulfoxide;