N,N'-(1,3-phenylenebis(4-(3,5-bis(trifluoromethyl)phenyl)but-3-yne-1,1-diyl))bis(4-methylbenzenesulfonamide)

Base Information

Chemical Name:N,N'-(1,3-phenylenebis(4-(3,5-bis(trifluoromethyl)phenyl)but-3-yne-1,1-diyl))bis(4-methylbenzenesulfonamide)
CAS No.:1619919-72-0
Molecular Formula:C₄₄H₃₂F₁₂N₂O₄S₂
Molecular Weight:944.862
Hs Code.:

Synonyms:N,N'-(1,3-phenylenebis(4-(3,5-bis(trifluoromethyl)phenyl)but-3-yne-1,1-diyl))bis(4-methylbenzenesulfonamide)

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Chemical Property of N,N'-(1,3-phenylenebis(4-(3,5-bis(trifluoromethyl)phenyl)but-3-yne-1,1-diyl))bis(4-methylbenzenesulfonamide)

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Technology Process of N,N'-(1,3-phenylenebis(4-(3,5-bis(trifluoromethyl)phenyl)but-3-yne-1,1-diyl))bis(4-methylbenzenesulfonamide)

There total 3 articles about N,N'-(1,3-phenylenebis(4-(3,5-bis(trifluoromethyl)phenyl)but-3-yne-1,1-diyl))bis(4-methylbenzenesulfonamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 328-70-1
3,6-bis(trifluoromethyl)bromobenzene

: 1619919-70-8
N,N'-(1,3-phenylenebis(but-3-yne-1,1-diyl))bis(4-methylbenzenesulfonamide)

: 1619919-72-0
N,N'-(1,3-phenylenebis(4-(3,5-bis(trifluoromethyl)phenyl)but-3-yne-1,1-diyl))bis(4-methylbenzenesulfonamide)

Guidance literature:: With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In N,N-dimethyl-formamide; at 80 ℃; for 24h; Schlenk technique; Inert atmosphere;
DOI:10.1039/c4ob00357h

Reference yield:

: 70-55-3
toluene-4-sulfonamide

: 1619919-72-0
N,N'-(1,3-phenylenebis(4-(3,5-bis(trifluoromethyl)phenyl)but-3-yne-1,1-diyl))bis(4-methylbenzenesulfonamide)

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / toluene / 150 °C / Inert atmosphere; Dean-Stark

2.1: zinc / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; piperidine / N,N-dimethyl-formamide / 24 h / 80 °C / Schlenk technique; Inert atmosphere

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; boron trifluoride diethyl etherate; zinc; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; 2.1: |Barbier Coupling Reaction / 2.2: |Barbier Coupling Reaction / 3.1: |Sonogashira Cross-Coupling;
DOI:10.1039/c4ob00357h

Reference yield:

: 615565-35-0
N,N'-(1,3-phenylenebis(methanylidene))bis(4-methylbenzenesulfonamide)

: 1619919-72-0
N,N'-(1,3-phenylenebis(4-(3,5-bis(trifluoromethyl)phenyl)but-3-yne-1,1-diyl))bis(4-methylbenzenesulfonamide)

Guidance literature:: Multi-step reaction with 2 steps

1.1: zinc / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; piperidine / N,N-dimethyl-formamide / 24 h / 80 °C / Schlenk technique; Inert atmosphere

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; zinc; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: |Barbier Coupling Reaction / 1.2: |Barbier Coupling Reaction / 2.1: |Sonogashira Cross-Coupling;
DOI:10.1039/c4ob00357h