1,3-bis(5-(3,5-bis(trifluoromethyl)phenyl)-1H-pyrrol-2-yl)benzene

Base Information

• Chemical Name: 1,3-bis(5-(3,5-bis(trifluoromethyl)phenyl)-1H-pyrrol-2-yl)benzene
• CAS No.: 1619919-80-0
• Molecular Formula: C₃₀H₁₆F₁₂N₂
• Molecular Weight: 632.451
• Mol file: 1619919-80-0.mol

Synonyms:1,3-bis(5-(3,5-bis(trifluoromethyl)phenyl)-1H-pyrrol-2-yl)benzene

Chemical Property of 1,3-bis(5-(3,5-bis(trifluoromethyl)phenyl)-1H-pyrrol-2-yl)benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-bis(5-(3,5-bis(trifluoromethyl)phenyl)-1H-pyrrol-2-yl)benzene

There total 2 articles about 1,3-bis(5-(3,5-bis(trifluoromethyl)phenyl)-1H-pyrrol-2-yl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

N,N'-(1,3-phenylenebis(4-(3,5-bis(trifluoromethyl)phenyl)but-3-yne-1,1-diyl))bis(4-methylbenzenesulfonamide) (1619919-72-0) → 1,3-bis(5-(3,5-bis(trifluoromethyl)phenyl)-1H-pyrrol-2-yl)benzene (1619919-80-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In N,N-dimethyl-formamide; at 80 ℃; for 48h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c4ob00357h

Reference yield:

N,N'-(1,3-phenylenebis(methanylidene))bis(4-methylbenzenesulfonamide) (615565-35-0) → 1,3-bis(5-(3,5-bis(trifluoromethyl)phenyl)-1H-pyrrol-2-yl)benzene (1619919-80-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: zinc / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; piperidine / N,N-dimethyl-formamide / 24 h / 80 °C / Schlenk technique; Inert atmosphere

3.1: tetrabutyl ammonium fluoride / N,N-dimethyl-formamide / 48 h / 80 °C / Schlenk technique; Inert atmosphere

With piperidine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; zinc; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: |Barbier Coupling Reaction / 1.2: |Barbier Coupling Reaction / 2.1: |Sonogashira Cross-Coupling;

DOI:10.1039/c4ob00357h

Reference yield:

1,3-bis(5-(3,5-bis(trifluoromethyl)phenyl)-1H-pyrrol-2-yl)benzene (1619919-80-0) + tetraethylammonium bicarbonate (17351-61-0) → C30H16F12N2*C8H20N(1+)*CHO3(1-)

Guidance literature:

In acetonitrile; at 24.84 ℃;

DOI:10.1039/c4ob00357h

upstream raw materials:

N,N'-(1,3-phenylenebis(methanylidene))bis(4-methylbenzenesulfonamide)

N,N'-(1,3-phenylenebis(4-(3,5-bis(trifluoromethyl)phenyl)but-3-yne-1,1-diyl))bis(4-methylbenzenesulfonamide)

Downstream raw materials:

C₃₀H₁₆F₁₂N₂*C₁₆H₃₆N⁽¹⁺⁾*C₂H₃O₂^(1-)