5-(2-Hydroxy-ethyl)-1-{(3aR,4R,6R,6aR)-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:5-(2-Hydroxy-ethyl)-1-{(3aR,4R,6R,6aR)-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-1H-pyrimidine-2,4-dione
CAS No.:173977-80-5
Molecular Formula:C₃₄H₃₆N₂O₈
Molecular Weight:600.668
Hs Code.:

5-(2-Hydroxy-ethyl)-1-{(3aR,4R,6R,6aR)-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-1H-pyrimidine-2,4-dione

Synonyms:5-(2-Hydroxy-ethyl)-1-{(3aR,4R,6R,6aR)-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-1H-pyrimidine-2,4-dione

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Chemical Property of 5-(2-Hydroxy-ethyl)-1-{(3aR,4R,6R,6aR)-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-1H-pyrimidine-2,4-dione

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Technology Process of 5-(2-Hydroxy-ethyl)-1-{(3aR,4R,6R,6aR)-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-1H-pyrimidine-2,4-dione

There total 4 articles about 5-(2-Hydroxy-ethyl)-1-{(3aR,4R,6R,6aR)-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 173977-79-2
(1-{(3aR,4R,6R,6aR)-6-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetic acid

: 173977-80-5
5-(2-Hydroxy-ethyl)-1-{(3aR,4R,6R,6aR)-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-1H-pyrimidine-2,4-dione

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran;
DOI:10.1021/jo951756x

Reference yield:

: 173977-78-1
(1-{(3aR,4R,6R,6aR)-6-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetonitrile

: 173977-80-5
5-(2-Hydroxy-ethyl)-1-{(3aR,4R,6R,6aR)-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH / methanol / 18 h / 80 °C

2: 71 percent / BH₃*SMe₂ / tetrahydrofuran / 5 h / Ambient temperature

With sodium hydroxide; dimethylsulfide borane complex; In tetrahydrofuran; methanol;
DOI:10.1080/07328319708006125

Reference yield:

: 14470-28-1
mono-4-methoxytrityl chloride

: 173977-80-5
5-(2-Hydroxy-ethyl)-1-{(3aR,4R,6R,6aR)-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / pyridine / 15 h / Ambient temperature

2: 83 percent / NaOH / ethanol / 36 h / 80 °C

3: 71 percent / borane-methyl sulfide complex / tetrahydrofuran

With pyridine; sodium hydroxide; dimethylsulfide borane complex; In tetrahydrofuran; ethanol;
DOI:10.1021/jo951756x