(1-{(3aR,4R,6R,6aR)-6-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetonitrile

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Chemical Name:(1-{(3aR,4R,6R,6aR)-6-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetonitrile
CAS No.:173977-78-1
Molecular Formula:C₃₄H₃₃N₃O₇
Molecular Weight:595.652
Hs Code.:

(1-{(3aR,4R,6R,6aR)-6-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetonitrile

Synonyms:(1-{(3aR,4R,6R,6aR)-6-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetonitrile

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Chemical Property of (1-{(3aR,4R,6R,6aR)-6-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetonitrile

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Technology Process of (1-{(3aR,4R,6R,6aR)-6-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetonitrile

There total 1 articles about (1-{(3aR,4R,6R,6aR)-6-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 14470-28-1
mono-4-methoxytrityl chloride

: 58479-72-4
[1-(O²,O³-isopropylidene-β-D-ribofuranosyl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetonitrile

: 173977-78-1
(1-{(3aR,4R,6R,6aR)-6-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetonitrile

Guidance literature:: With pyridine; for 15h; Ambient temperature;
DOI:10.1021/jo951756x

Reference yield: 83.0%

: 173977-78-1
(1-{(3aR,4R,6R,6aR)-6-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetonitrile

: 173977-79-2
(1-{(3aR,4R,6R,6aR)-6-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 80 ℃; for 36h;
DOI:10.1021/jo951756x

Reference yield:

: 173977-78-1
(1-{(3aR,4R,6R,6aR)-6-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetonitrile

: 173977-80-5
5-(2-Hydroxy-ethyl)-1-{(3aR,4R,6R,6aR)-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH / methanol / 18 h / 80 °C

2: 71 percent / BH₃*SMe₂ / tetrahydrofuran / 5 h / Ambient temperature

With sodium hydroxide; dimethylsulfide borane complex; In tetrahydrofuran; methanol;
DOI:10.1080/07328319708006125