Thiophosphoric acid O-{2-[1-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-ethyl} ester S-phenyl ester

Base Information

Chemical Name:Thiophosphoric acid O-{2-[1-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-ethyl} ester S-phenyl ester
CAS No.:198822-75-2
Molecular Formula:C₂₀H₂₅N₂O₉PS
Molecular Weight:500.466
Hs Code.:

Thiophosphoric acid O-{2-[1-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-ethyl} ester S-phenyl ester

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Chemical Property of Thiophosphoric acid O-{2-[1-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-ethyl} ester S-phenyl ester

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Technology Process of Thiophosphoric acid O-{2-[1-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-ethyl} ester S-phenyl ester

There total 5 articles about Thiophosphoric acid O-{2-[1-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-ethyl} ester S-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 198822-74-1
Dithiophosphoric acid O-{2-[1-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-ethyl} ester S,S'-diphenyl ester

: 198822-75-2
Thiophosphoric acid O-{2-[1-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-ethyl} ester S-phenyl ester

Guidance literature:: With bis(tri-n-butyltin)oxide; In pyridine; for 3h; Yield given; Ambient temperature;
DOI:10.1080/07328319708006125

Reference yield:

: 173977-80-5
5-(2-Hydroxy-ethyl)-1-{(3aR,4R,6R,6aR)-6-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-1H-pyrimidine-2,4-dione

: 198822-75-2
Thiophosphoric acid O-{2-[1-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-ethyl} ester S-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / DDS, 1H-tetrazole

2: 92 percent / TFA / CH₂Cl₂ / 0.5 h / Ambient temperature

3: (Bu₃Sn)2O / pyridine / 3 h / Ambient temperature

With 1H-tetrazole; trifluoroacetic acid; bis(tri-n-butyltin)oxide; dapsone; In pyridine; dichloromethane;
DOI:10.1080/07328319708006125

Reference yield:

: 173977-79-2
(1-{(3aR,4R,6R,6aR)-6-[(4-Methoxy-phenyl)-diphenyl-methoxymethyl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-acetic acid

: 198822-75-2
Thiophosphoric acid O-{2-[1-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-ethyl} ester S-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / BH₃*SMe₂ / tetrahydrofuran / 5 h / Ambient temperature

2: 66 percent / DDS, 1H-tetrazole

3: 92 percent / TFA / CH₂Cl₂ / 0.5 h / Ambient temperature

4: (Bu₃Sn)2O / pyridine / 3 h / Ambient temperature

With 1H-tetrazole; dimethylsulfide borane complex; trifluoroacetic acid; bis(tri-n-butyltin)oxide; dapsone; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1080/07328319708006125