(E)-4-<2(R)-5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>-2-butenoic acid ethyl ester

Base Information

Chemical Name:(E)-4-<2(R)-5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>-2-butenoic acid ethyl ester
CAS No.:131879-90-8
Molecular Formula:C₁₇H₂₁NO₃
Molecular Weight:287.359
Hs Code.:

Synonyms:(E)-4-<2(R)-5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>-2-butenoic acid ethyl ester

Suppliers and Price of (E)-4-<2(R)-5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>-2-butenoic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-4-<2(R)-5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>-2-butenoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-4-<2(R)-5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>-2-butenoic acid ethyl ester

There total 10 articles about (E)-4-<2(R)-5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>-2-butenoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

: 131879-89-5
(S)-5-oxo-1-(phenylmethyl)-2-pyrrolidineacetaldehyde

: 1099-45-2
ethyl (triphenylphosphoranylidene)acetate

: 131879-90-8
(E)-4-<2(R)-5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>-2-butenoic acid ethyl ester

Guidance literature:: In toluene; at 90 ℃; for 5.5h;
DOI:10.1021/jm00015a009

Reference yield:

: 56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6
L-glutamic acid

: 131879-90-8
(E)-4-<2(R)-5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>-2-butenoic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) NaBH₄, NaOH, 2.) 6N HCl / H₂O / 1.) from 10 to 15 deg C, 30 min, 2.) RT, overnight

2: 55 percent / aq. HCl / Heating

3: 132 g / conc. H₂SO₄ / toluene / Heating

4: 77 percent / NaBH₄, MeOH / 2-methyl-propan-2-ol / Ambient temperature

5: DMAP / CH₂Cl₂ / Ambient temperature

6: NaI / acetone / Heating

7: 66 percent / Li₂CuCl₄ / tetrahydrofuran / -78 °C

8: 84.4 percent / 1.) O₃, 2.) aq. Me₂S / methanol; CH₂Cl₂ / 6.5 h / -78 °C

9: 95.6 percent / toluene / 5.5 h / 90 °C

With hydrogenchloride; methanol; dmap; sodium hydroxide; sodium tetrahydroborate; dilithium tetrachlorocuprate; dimethylsulfide; sulfuric acid; ozone; sodium iodide; In tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene; tert-butyl alcohol;
DOI:10.1021/jm00015a009

Reference yield:

: 77539-18-5,73914-82-6
(S)-(+)-2-benzylamino glutaric acid

: 131879-90-8
(E)-4-<2(R)-5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>-2-butenoic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 55 percent / aq. HCl / Heating

2: 132 g / conc. H₂SO₄ / toluene / Heating

3: 77 percent / NaBH₄, MeOH / 2-methyl-propan-2-ol / Ambient temperature

4: DMAP / CH₂Cl₂ / Ambient temperature

5: NaI / acetone / Heating

6: 66 percent / Li₂CuCl₄ / tetrahydrofuran / -78 °C

7: 84.4 percent / 1.) O₃, 2.) aq. Me₂S / methanol; CH₂Cl₂ / 6.5 h / -78 °C

8: 95.6 percent / toluene / 5.5 h / 90 °C

With hydrogenchloride; methanol; dmap; sodium tetrahydroborate; dilithium tetrachlorocuprate; dimethylsulfide; sulfuric acid; ozone; sodium iodide; In tetrahydrofuran; methanol; dichloromethane; acetone; toluene; tert-butyl alcohol;
DOI:10.1021/jm00015a009