C₂₁H₁₈BrNO₅

Base Information

• Chemical Name: C₂₁H₁₈BrNO₅
• CAS No.: 1491026-46-0
• Molecular Formula: C₂₁H₁₈BrNO₅
• Molecular Weight: 444.282
• Mol file: 1491026-46-0.mol

Synonyms:C₂₁H₁₈BrNO₅

Chemical Property of C₂₁H₁₈BrNO₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₈BrNO₅

There total 9 articles about C₂₁H₁₈BrNO₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

C33H28NO9P (1491026-45-9) → C21H18BrNO5 (1491026-46-0)

Guidance literature:

With hydrogen bromide; In acetic acid; at 20 ℃; for 3h; Inert atmosphere;

Reference yield: 69.0%

C33H28NO9P (1491026-79-9) → C21H18BrNO5 (1491026-46-0)

Guidance literature:

With hydrogen bromide; In acetic acid; at 20 ℃; for 3h; Inert atmosphere;

Reference yield:

(4S,5R)-ethyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-meth-yl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide (879551-01-6) → C21H18BrNO5 (1491026-46-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: N,N-dimethyl-formamide; water / 5 h / 50 °C / Large scale

1.2: 30 °C / Large scale

2.1: hydrogenchloride / ethanol / 15 h / 20 - 30 °C

3.1: triethylamine; dmap / acetonitrile / 2.5 h / 0 - 25 °C

4.1: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / -30 °C

5.1: triethylamine / toluene / 5 h / 20 °C

6.1: hydrogen bromide / acetic acid / 3 h / 20 °C / Inert atmosphere

With hydrogenchloride; dmap; hydrogen bromide; lithium tri-t-butoxyaluminum hydride; triethylamine; In tetrahydrofuran; ethanol; water; acetic acid; N,N-dimethyl-formamide; toluene; acetonitrile;

upstream raw materials:

C₁₁H₁₈O₄

(2S,3R)-3-[(4R)-2,2-dimethyl-[1,3]dioxolane-4-yl]-2,3-dihydroxy-2-methylpropionic acid ethyl ester

(4S,5R)-ethyl-5-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-4-meth-yl-1,3,2-dioxathiolane-4-carboxylate 2,2-dioxide

C₁₁H₁₈O₇S

Refernces