7-(3-chloro-phenyl)-7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7H-pyrrolo[3,4-b]pyrazin-5-ylamine

Base Information

Chemical Name:7-(3-chloro-phenyl)-7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7H-pyrrolo[3,4-b]pyrazin-5-ylamine
CAS No.:1260248-48-3
Molecular Formula:C₂₃H₂₁ClN₄O
Molecular Weight:404.899
Hs Code.:

Synonyms:7-(3-chloro-phenyl)-7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7H-pyrrolo[3,4-b]pyrazin-5-ylamine

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Chemical Property of 7-(3-chloro-phenyl)-7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7H-pyrrolo[3,4-b]pyrazin-5-ylamine

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Technology Process of 7-(3-chloro-phenyl)-7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7H-pyrrolo[3,4-b]pyrazin-5-ylamine

There total 5 articles about 7-(3-chloro-phenyl)-7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7H-pyrrolo[3,4-b]pyrazin-5-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1260248-47-2
5-bromo-1-cyclopropyl-2-methoxy-3-methyl-benzene

: 1260248-37-0
N-((3-chlorophenyl)(3-cyanopyrazin-2-yl)methylene)-2-methylpropane-2-sulfinamide

: 1260248-48-3
7-(3-chloro-phenyl)-7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7H-pyrrolo[3,4-b]pyrazin-5-ylamine

Guidance literature:: 5-bromo-1-cyclopropyl-2-methoxy-3-methyl-benzene; With magnesium; lithium chloride; diisobutylaluminium hydride; In tetrahydrofuran; at 20 - 35 ℃; for 0.5h; Inert atmosphere;

N-((3-chlorophenyl)(3-cyanopyrazin-2-yl)methylene)-2-methylpropane-2-sulfinamide; In tetrahydrofuran; at 0 - 20 ℃; for 4h;

With hydrogenchloride; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

Reference yield:

: 499236-68-9
2-cyclopropyl-6-methylphenol

: 1260248-48-3
7-(3-chloro-phenyl)-7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7H-pyrrolo[3,4-b]pyrazin-5-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: bromine / dichloromethane / 1 h / 0 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 3 h / 0 - 20 °C

3.1: magnesium; lithium chloride / diisobutylaluminium hydride / tetrahydrofuran / 0.5 h / 20 - 35 °C / Inert atmosphere

3.2: 4 h / 0 - 20 °C

3.3: 2 h / 20 °C

With bromine; potassium carbonate; magnesium; lithium chloride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 854260-75-6
2-(allyloxy)-1-bromo-3-methylbenzene

: 1260248-48-3
7-(3-chloro-phenyl)-7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7H-pyrrolo[3,4-b]pyrazin-5-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: bromine / dichloromethane / 1 h / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 3 h / 0 - 20 °C

4.1: magnesium; lithium chloride / diisobutylaluminium hydride / tetrahydrofuran / 0.5 h / 20 - 35 °C / Inert atmosphere

4.2: 4 h / 0 - 20 °C

4.3: 2 h / 20 °C

With bromine; tert.-butyl lithium; potassium carbonate; magnesium; lithium chloride; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; pentane;