Technology Process of 7-(3-chloro-phenyl)-7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7H-pyrrolo[3,4-b]pyrazin-5-ylamine
There total 5 articles about 7-(3-chloro-phenyl)-7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7H-pyrrolo[3,4-b]pyrazin-5-ylamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
5-bromo-1-cyclopropyl-2-methoxy-3-methyl-benzene;
With
magnesium; lithium chloride;
diisobutylaluminium hydride;
In
tetrahydrofuran;
at 20 - 35 ℃;
for 0.5h;
Inert atmosphere;
N-((3-chlorophenyl)(3-cyanopyrazin-2-yl)methylene)-2-methylpropane-2-sulfinamide;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 4h;
With
hydrogenchloride;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 2h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: bromine / dichloromethane / 1 h / 0 - 20 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C
2.2: 3 h / 0 - 20 °C
3.1: magnesium; lithium chloride / diisobutylaluminium hydride / tetrahydrofuran / 0.5 h / 20 - 35 °C / Inert atmosphere
3.2: 4 h / 0 - 20 °C
3.3: 2 h / 20 °C
With
bromine; potassium carbonate; magnesium; lithium chloride;
diisobutylaluminium hydride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C
1.2: -78 - 20 °C
2.1: bromine / dichloromethane / 1 h / 0 - 20 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C
3.2: 3 h / 0 - 20 °C
4.1: magnesium; lithium chloride / diisobutylaluminium hydride / tetrahydrofuran / 0.5 h / 20 - 35 °C / Inert atmosphere
4.2: 4 h / 0 - 20 °C
4.3: 2 h / 20 °C
With
bromine; tert.-butyl lithium; potassium carbonate; magnesium; lithium chloride;
diisobutylaluminium hydride;
In
tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; pentane;