7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7-(3-pyrimidin-5-yl-phenyl)-7H-pyrrolo[3,4-b] pyrazin-5-ylamine

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Chemical Name:7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7-(3-pyrimidin-5-yl-phenyl)-7H-pyrrolo[3,4-b] pyrazin-5-ylamine
CAS No.:1260248-17-6
Molecular Formula:C₂₇H₂₄N₆O
Molecular Weight:448.527
Hs Code.:

Synonyms:7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7-(3-pyrimidin-5-yl-phenyl)-7H-pyrrolo[3,4-b] pyrazin-5-ylamine

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Chemical Property of 7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7-(3-pyrimidin-5-yl-phenyl)-7H-pyrrolo[3,4-b] pyrazin-5-ylamine

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Technology Process of 7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7-(3-pyrimidin-5-yl-phenyl)-7H-pyrrolo[3,4-b] pyrazin-5-ylamine

There total 6 articles about 7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7-(3-pyrimidin-5-yl-phenyl)-7H-pyrrolo[3,4-b] pyrazin-5-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1260248-48-3
7-(3-chloro-phenyl)-7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7H-pyrrolo[3,4-b]pyrazin-5-ylamine

: 109299-78-7
pyrimidine 5-boronic acid

: 1260248-17-6
7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7-(3-pyrimidin-5-yl-phenyl)-7H-pyrrolo[3,4-b] pyrazin-5-ylamine

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In Dimethyl ether; at 120 ℃; for 1h; Microwave irradiation;

Reference yield:

: 499236-68-9
2-cyclopropyl-6-methylphenol

: 1260248-17-6
7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7-(3-pyrimidin-5-yl-phenyl)-7H-pyrrolo[3,4-b] pyrazin-5-ylamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine / dichloromethane / 1 h / 0 - 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 3 h / 0 - 20 °C

3.1: magnesium; lithium chloride / diisobutylaluminium hydride / tetrahydrofuran / 0.5 h / 20 - 35 °C / Inert atmosphere

3.2: 4 h / 0 - 20 °C

3.3: 2 h / 20 °C

4.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / Dimethyl ether / 1 h / 120 °C / Microwave irradiation

With potassium phosphate; bromine; potassium carbonate; magnesium; lithium chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; diisobutylaluminium hydride; XPhos; In tetrahydrofuran; Dimethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 854260-75-6
2-(allyloxy)-1-bromo-3-methylbenzene

: 1260248-17-6
7-(3-cyclopropyl-4-methoxy-5-methyl-phenyl)-7-(3-pyrimidin-5-yl-phenyl)-7H-pyrrolo[3,4-b] pyrazin-5-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: bromine / dichloromethane / 1 h / 0 - 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 3 h / 0 - 20 °C

4.1: magnesium; lithium chloride / diisobutylaluminium hydride / tetrahydrofuran / 0.5 h / 20 - 35 °C / Inert atmosphere

4.2: 4 h / 0 - 20 °C

4.3: 2 h / 20 °C

5.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / Dimethyl ether / 1 h / 120 °C / Microwave irradiation

With potassium phosphate; bromine; tert.-butyl lithium; potassium carbonate; magnesium; lithium chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; diisobutylaluminium hydride; XPhos; In tetrahydrofuran; diethyl ether; Dimethyl ether; dichloromethane; N,N-dimethyl-formamide; pentane;