1-Methoxy-3-methylbutan-2-amine

Base Information

• Chemical Name: 1-Methoxy-3-methylbutan-2-amine
• CAS No.: 127180-89-6
• Molecular Formula: C₆H₁₅NO
• Molecular Weight: 117.191
• European Community (EC) Number: 874-242-8
• Mol file: 127180-89-6.mol

Synonyms:1-methoxy-3-methylbutan-2-amine;127180-89-6;1-Methoxymethyl-2-methyl-propylamine;SCHEMBL10057895;SCHEMBL13088426;MFCD06248008;AKOS010815368;AT12989;SB32601;SB34153;SB38119;BB 0253901;EN300-85575;Z825742262

Chemical Property of 1-Methoxy-3-methylbutan-2-amine

Chemical Property:

• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 117.115364102
• Heavy Atom Count: 8
• Complexity: 54.5

Purity/Quality:

97% ^*data from raw suppliers

1-Methoxy-3-methylbutan-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)C(COC)N

Technology Process of 1-Methoxy-3-methylbutan-2-amine

There total 3 articles about 1-Methoxy-3-methylbutan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

valinol (16369-05-4,473-75-6) + methyl iodide (74-88-4) → N-Methylvalinol (78617-54-6) + 1-methoxy-3-methyl-2-butanamine (127180-89-6)

Guidance literature:

With sodium hydride;

DOI:10.1021/jo00298a018

Reference yield:

valine ethyl ester (13893-45-3) → 1-methoxy-3-methyl-2-butanamine (127180-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / LiAlH₄

2: 43 percent / NaH

With lithium aluminium tetrahydride; sodium hydride;

DOI:10.1021/jo00298a018

Reference yield:

D,L-valine (516-06-3,25609-85-2,7004-03-7,921-10-8) → 1-methoxy-3-methyl-2-butanamine (127180-89-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent

2: 82 percent / LiAlH₄

3: 43 percent / NaH

With lithium aluminium tetrahydride; sodium hydride;

DOI:10.1021/jo00298a018

upstream raw materials:

valinol

methyl iodide

valine ethyl ester

D,L-valine

Downstream raw materials:

(+/-)-2-N-methoxy-N-(1'-phenylethyl)-1-methoxy-3-methyl-2-butanamine

(1'R*,2R*)-N-hydroxy-N-(1'-phenylethyl)-1-methoxy-3-methyl-2-butanamine

(1'R*,2S*)-N-hydroxy-N-(1'-phenylethyl)-1-methoxy-3-methyl-2-butanamine

N-benzylidene-1-methoxy-3-methyl-2-butanamine N-oxide