C₃₃H₄₀N₈O₅

Base Information

• Chemical Name: C₃₃H₄₀N₈O₅
• CAS No.: 1426343-05-6
• Molecular Formula: C₃₃H₄₀N₈O₅
• Molecular Weight: 628.731
• Mol file: 1426343-05-6.mol

Synonyms:C₃₃H₄₀N₈O₅

Chemical Property of C₃₃H₄₀N₈O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₃H₄₀N₈O₅

There total 10 articles about C₃₃H₄₀N₈O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

C33H40N8O5 (1426343-03-4) → C33H40N8O5 (1426343-05-6)

Guidance literature:

With tetrakis(acetonitrile)copper(I)tetrafluoroborate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In dichloromethane; at 55 ℃; for 12h; Reagent/catalyst; Time; Temperature; Solvent; Inert atmosphere;

DOI:10.1021/ol303572t

Reference yield:

ethyl 5-azidovalerate (89896-39-9) → C33H40N8O5 (1426343-05-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium hydroxide / water; methanol / 0 - 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.08 h / 0 °C

2.2: 0 °C

3.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 0 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.08 h / 0 °C

4.2: 0 °C

5.1: tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; tetrakis(acetonitrile)copper(I)tetrafluoroborate / dichloromethane / 12 h / 55 °C / Inert atmosphere

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; tetrakis(acetonitrile)copper(I)tetrafluoroborate; lithium hydroxide monohydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ol303572t

Reference yield:

ethyl 5-bromovalerate (14660-52-7) → C33H40N8O5 (1426343-05-6)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium azide / acetone; water / Reflux

2.1: potassium hydroxide / water; methanol / 0 - 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.08 h / 0 °C

3.2: 0 °C

4.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 0 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole; 4-methyl-morpholine / N,N-dimethyl-formamide / 0.08 h / 0 °C

5.2: 0 °C

6.1: tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; tetrakis(acetonitrile)copper(I)tetrafluoroborate / dichloromethane / 12 h / 55 °C / Inert atmosphere

With 4-methyl-morpholine; sodium azide; 1-hydroxy-7-aza-benzotriazole; tetrakis(acetonitrile)copper(I)tetrafluoroborate; lithium hydroxide monohydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;

DOI:10.1021/ol303572t

upstream raw materials:

ethyl 5-azidovalerate

ethyl 5-bromovalerate

5-azidovaleric acid

[2-phenyl-1-(prop-2-ynylcarbamoylmethyl-carbamoyl)-ethyl]-carbamic acid tert-butyl ester