N-α-methyl benzyl-O-benzoyl hydroxylamine hydrochloride

Base Information

• Chemical Name: N-α-methyl benzyl-O-benzoyl hydroxylamine hydrochloride
• CAS No.: 127104-39-6
• Molecular Formula: C₁₅H₁₅NO₂*ClH
• Molecular Weight: 277.751
• Mol file: 127104-39-6.mol

Synonyms:N-α-methyl benzyl-O-benzoyl hydroxylamine hydrochloride

Chemical Property of N-α-methyl benzyl-O-benzoyl hydroxylamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-α-methyl benzyl-O-benzoyl hydroxylamine hydrochloride

There total 3 articles about N-α-methyl benzyl-O-benzoyl hydroxylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

Phenylglycinol (20989-17-7,56613-80-0,71006-16-1,7568-92-5,188586-38-1) + dibenzoyl peroxide (94-36-0) → N-α-methyl benzyl-O-benzoyl hydroxylamine hydrochloride (127104-39-6)

Guidance literature:

With disodium hydrogenphosphate; In tetrahydrofuran; at 25 ℃; for 3h;

DOI:10.1021/jo00298a018

Reference yield:

ethyl 2-phenyl-2-aminoacetate (6097-58-1,6152-27-8,15962-49-9,39251-40-6) → N-α-methyl benzyl-O-benzoyl hydroxylamine hydrochloride (127104-39-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / LiAlH₄

2: 66 percent / Na₂HPO₄ / tetrahydrofuran / 3 h / 25 °C

With disodium hydrogenphosphate; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jo00298a018

Reference yield:

phenylglycin (2835-06-5) → N-α-methyl benzyl-O-benzoyl hydroxylamine hydrochloride (127104-39-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent

2: 72 percent / LiAlH₄

3: 66 percent / Na₂HPO₄ / tetrahydrofuran / 3 h / 25 °C

With disodium hydrogenphosphate; lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/jo00298a018

upstream raw materials:

Phenylglycinol

dibenzoyl peroxide

ethyl 2-phenyl-2-aminoacetate

phenylglycin

Downstream raw materials:

acetophenone

(R*,R*)-diethyl N,N-bis(1-phenylethyl)amino phosphate

(R*,S*)-diethyl N,N-bis(1-phenylethyl)amino phosphate

(R*,R*)-N-hydroxy-N-(1-phenylethyl)-1-phenylethanamine