2-(4-acetylamino-5-chloro-2-methoxy-3-nitrophenyl)-5-methyl-4-(3-pyridyl)imidazole

Base Information

Chemical Name:2-(4-acetylamino-5-chloro-2-methoxy-3-nitrophenyl)-5-methyl-4-(3-pyridyl)imidazole
CAS No.:156601-88-6
Molecular Formula:C₁₈H₁₆ClN₅O₄
Molecular Weight:401.809
Hs Code.:

Synonyms:2-(4-acetylamino-5-chloro-2-methoxy-3-nitrophenyl)-5-methyl-4-(3-pyridyl)imidazole

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Chemical Property of 2-(4-acetylamino-5-chloro-2-methoxy-3-nitrophenyl)-5-methyl-4-(3-pyridyl)imidazole

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Technology Process of 2-(4-acetylamino-5-chloro-2-methoxy-3-nitrophenyl)-5-methyl-4-(3-pyridyl)imidazole

There total 6 articles about 2-(4-acetylamino-5-chloro-2-methoxy-3-nitrophenyl)-5-methyl-4-(3-pyridyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.9%

: 1027193-54-9
N-[6-Chloro-4-(1-hydroxy-4-methyl-5-pyridin-3-yl-1H-imidazol-2-yl)-3-methoxy-2-nitro-phenyl]-acetamide

: 156601-88-6
2-(4-acetylamino-5-chloro-2-methoxy-3-nitrophenyl)-5-methyl-4-(3-pyridyl)imidazole

Guidance literature:: With triethyl phosphite; In N,N-dimethyl-formamide; at 80 ℃;
DOI:10.1248/cpb.42.560

Reference yield:

: 65882-96-4
1-hydroxyimino-1-(3-pyridyl)-2-propanone

: 156601-88-6
2-(4-acetylamino-5-chloro-2-methoxy-3-nitrophenyl)-5-methyl-4-(3-pyridyl)imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate / acetic acid / 0.25 h / 100 °C

2: 59.9 percent / P(OEt)3 / dimethylformamide / 80 °C

With ammonium acetate; triethyl phosphite; In acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.560

Reference yield:

: 4093-31-6
methyl 2-methoxy 4-acetamido 5-chloro benzoate

: 156601-88-6
2-(4-acetylamino-5-chloro-2-methoxy-3-nitrophenyl)-5-methyl-4-(3-pyridyl)imidazole

Guidance literature:: Multi-step reaction with 5 steps

1: 93.8 percent / HNO₃ fuming / 0.17 h / -35 - -30 °C

2: LiAlH₄ / tetrahydrofuran / 2 h / -30 °C

3: 84 percent / MnO₂ / ethyl acetate / 6 h / Heating

4: ammonium acetate / acetic acid / 0.25 h / 100 °C

5: 59.9 percent / P(OEt)3 / dimethylformamide / 80 °C

With ammonium acetate; manganese(IV) oxide; lithium aluminium tetrahydride; nitric acid; triethyl phosphite; In tetrahydrofuran; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.42.560