(R)-2-Acetylamino-3-[(S)-5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophene-2-sulfinyl]-propionic acid 2-methoxy-ethoxymethyl ester

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Chemical Name:(R)-2-Acetylamino-3-[(S)-5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophene-2-sulfinyl]-propionic acid 2-methoxy-ethoxymethyl ester
CAS No.:195704-98-4
Molecular Formula:C₂₆H₂₈FNO₈S₃
Molecular Weight:597.707
Hs Code.:

Synonyms:(R)-2-Acetylamino-3-[(S)-5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophene-2-sulfinyl]-propionic acid 2-methoxy-ethoxymethyl ester

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Chemical Property of (R)-2-Acetylamino-3-[(S)-5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophene-2-sulfinyl]-propionic acid 2-methoxy-ethoxymethyl ester

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Technology Process of (R)-2-Acetylamino-3-[(S)-5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophene-2-sulfinyl]-propionic acid 2-methoxy-ethoxymethyl ester

There total 3 articles about (R)-2-Acetylamino-3-[(S)-5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophene-2-sulfinyl]-propionic acid 2-methoxy-ethoxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 195704-96-2
(R)-2-Acetylamino-3-[5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophen-2-ylsulfanyl]-propionic acid 2-methoxy-ethoxymethyl ester

: 195704-98-4
(R)-2-Acetylamino-3-[(S)-5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophene-2-sulfinyl]-propionic acid 2-methoxy-ethoxymethyl ester

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -78 ℃;
DOI:10.1016/S0960-894X(97)00363-6

Reference yield:

: 169515-92-8
(R)-2-Acetylamino-3-[5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophen-2-ylsulfanyl]-propionic acid

: 195704-98-4
(R)-2-Acetylamino-3-[(S)-5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophene-2-sulfinyl]-propionic acid 2-methoxy-ethoxymethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / i-Pr₂NEt / dimethylformamide / Ambient temperature

2: 68 percent / m-CPBA / CH₂Cl₂ / -78 °C

With N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(97)00363-6

Reference yield:

: 169515-94-0
C₃₄H₂₄F₂O₄S₆

: 195704-98-4
(R)-2-Acetylamino-3-[(S)-5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophene-2-sulfinyl]-propionic acid 2-methoxy-ethoxymethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-Bu₃P, 2.) 4 N HCl, 3.) Et₃N / 1.) THF, room temperature, 2.) AcOH, 100 deg C, 3.) Et₂O, H₂O, 0 deg C

2: 82 percent / i-Pr₂NEt / dimethylformamide / Ambient temperature

3: 68 percent / m-CPBA / CH₂Cl₂ / -78 °C

With hydrogenchloride; tributylphosphine; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(97)00363-6