(R)-2-Acetylamino-3-[5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophen-2-ylsulfanyl]-propionic acid 2-methoxy-ethoxymethyl ester

Base Information

• Chemical Name: (R)-2-Acetylamino-3-[5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophen-2-ylsulfanyl]-propionic acid 2-methoxy-ethoxymethyl ester
• CAS No.: 195704-96-2
• Molecular Formula: C₂₆H₂₈FNO₇S₃
• Molecular Weight: 581.707
• Mol file: 195704-96-2.mol

Synonyms:(R)-2-Acetylamino-3-[5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophen-2-ylsulfanyl]-propionic acid 2-methoxy-ethoxymethyl ester

Chemical Property of (R)-2-Acetylamino-3-[5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophen-2-ylsulfanyl]-propionic acid 2-methoxy-ethoxymethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-Acetylamino-3-[5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophen-2-ylsulfanyl]-propionic acid 2-methoxy-ethoxymethyl ester

There total 2 articles about (R)-2-Acetylamino-3-[5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophen-2-ylsulfanyl]-propionic acid 2-methoxy-ethoxymethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-Methoxyethoxymethyl chloride (3970-21-6) + (R)-2-Acetylamino-3-[5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophen-2-ylsulfanyl]-propionic acid (169515-92-8) → (R)-2-Acetylamino-3-[5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophen-2-ylsulfanyl]-propionic acid 2-methoxy-ethoxymethyl ester (195704-96-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1016/S0960-894X(97)00363-6

Reference yield:

C34H24F2O4S6 (169515-94-0) → (R)-2-Acetylamino-3-[5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophen-2-ylsulfanyl]-propionic acid 2-methoxy-ethoxymethyl ester (195704-96-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-Bu₃P, 2.) 4 N HCl, 3.) Et₃N / 1.) THF, room temperature, 2.) AcOH, 100 deg C, 3.) Et₂O, H₂O, 0 deg C

2: 82 percent / i-Pr₂NEt / dimethylformamide / Ambient temperature

With hydrogenchloride; tributylphosphine; triethylamine; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(97)00363-6

Reference yield: 68.0%

(R)-2-Acetylamino-3-[5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophen-2-ylsulfanyl]-propionic acid 2-methoxy-ethoxymethyl ester (195704-96-2) → (R)-2-Acetylamino-3-[(S)-5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophene-2-sulfinyl]-propionic acid 2-methoxy-ethoxymethyl ester (195704-98-4)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -78 ℃;

DOI:10.1016/S0960-894X(97)00363-6

upstream raw materials:

2-Methoxyethoxymethyl chloride

(R)-2-Acetylamino-3-[5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophen-2-ylsulfanyl]-propionic acid

C₃₄H₂₄F₂O₄S₆

Downstream raw materials:

(R)-2-Acetylamino-3-[(S)-5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophene-2-sulfinyl]-propionic acid 2-methoxy-ethoxymethyl ester