(+/-)-2-((Z)-5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid

Base Information

Chemical Name:(+/-)-2-((Z)-5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid
CAS No.:1349199-99-0
Molecular Formula:C₁₉H₁₅NO₄S₂
Molecular Weight:385.464
Hs Code.:

Synonyms:(+/-)-2-((Z)-5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid

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Chemical Property of (+/-)-2-((Z)-5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid

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Technology Process of (+/-)-2-((Z)-5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid

There total 3 articles about (+/-)-2-((Z)-5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 305378-01-2
C₁₂H₁₁NO₄S₂

: 100-52-7
benzaldehyde

: 1349199-99-0
(+/-)-2-((Z)-5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid

Guidance literature:: With 1-methyl-piperazine; ammonium acetate; In toluene; at 110 ℃; for 15h; Molecular sieve;
DOI:10.1016/j.bioorg.2012.08.002

Reference yield:

: 556-02-5,556-03-6,34537-57-0,55520-40-6,96946-98-4,60-18-4,18875-48-4,25619-78-7,30704-25-7
?Tyr

: 1349199-99-0
(+/-)-2-((Z)-5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; ammonia / 12.5 h / 0 - 5 °C

2.1: water / 0.5 h

2.2: 1 h / 5 - 10 °C

2.3: 3 h / 60 - 70 °C

3.1: 1-methyl-piperazine; ammonium acetate / toluene / 15 h / 110 °C / Molecular sieve

With 1-methyl-piperazine; ammonium acetate; ammonia; water; In water; toluene; 3.1: |Knoevenagel Condensation;
DOI:10.1016/j.bioorg.2012.08.002

Reference yield:

: C₁₀H₁₁NO₃S₂*2H₃N

: 1349199-99-0
(+/-)-2-((Z)-5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)-3-(4-hydroxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: water / 0.5 h

1.2: 1 h / 5 - 10 °C

1.3: 3 h / 60 - 70 °C

2.1: 1-methyl-piperazine; ammonium acetate / toluene / 15 h / 110 °C / Molecular sieve

With 1-methyl-piperazine; ammonium acetate; In water; toluene; 2.1: |Knoevenagel Condensation;
DOI:10.1016/j.bioorg.2012.08.002