Technology Process of ethyl (6S)-6-tert-butyldiphenylsilyloxyoct-7-enoate
There total 9 articles about ethyl (6S)-6-tert-butyldiphenylsilyloxyoct-7-enoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium iodide; zinc;
In
N,N-dimethyl-formamide;
at 90 ℃;
for 8h;
Inert atmosphere;
DOI:10.1016/j.tetasy.2011.02.008
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium acetate; pyridinium chlorochromate / dichloromethane / 3 h / 0 °C / Inert atmosphere
2.1: sodium hydride / tetrahydrofuran / 0.25 h / Inert atmosphere
2.2: 18 h / 0 - 25 °C / Inert atmosphere
3.1: palladium 10% on activated carbon; hydrogen / ethanol / 22 h / 25 °C
4.1: water; trifluoroacetic acid / dichloromethane / 27 h / 0 - 25 °C
5.1: pyridine / 24 h / 0 - 25 °C / Inert atmosphere
6.1: sodium iodide; zinc / N,N-dimethyl-formamide / 8 h / 90 °C / Inert atmosphere
With
pyridine; palladium 10% on activated carbon; water; hydrogen; sodium acetate; sodium hydride; pyridinium chlorochromate; trifluoroacetic acid; sodium iodide; zinc;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
2.1: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.tetasy.2011.02.008
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere
1.2: 15 h / 0 - 25 °C
2.1: sodium acetate; pyridinium chlorochromate / dichloromethane / 3 h / 0 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran / 0.25 h / Inert atmosphere
3.2: 18 h / 0 - 25 °C / Inert atmosphere
4.1: palladium 10% on activated carbon; hydrogen / ethanol / 22 h / 25 °C
5.1: water; trifluoroacetic acid / dichloromethane / 27 h / 0 - 25 °C
6.1: pyridine / 24 h / 0 - 25 °C / Inert atmosphere
7.1: sodium iodide; zinc / N,N-dimethyl-formamide / 8 h / 90 °C / Inert atmosphere
With
pyridine; dimethylsulfide borane complex; palladium 10% on activated carbon; water; hydrogen; sodium acetate; sodium hydride; pyridinium chlorochromate; trifluoroacetic acid; sodium iodide; zinc;
In
tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
3.1: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.tetasy.2011.02.008
