C₂₈H₄₂N₅O₁₄P

Base Information

• Chemical Name: C₂₈H₄₂N₅O₁₄P
• CAS No.: 1030021-96-5
• Molecular Formula: C₂₈H₄₂N₅O₁₄P
• Molecular Weight: 703.64
• Mol file: 1030021-96-5.mol

Synonyms:C₂₈H₄₂N₅O₁₄P

Chemical Property of C₂₈H₄₂N₅O₁₄P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₄₂N₅O₁₄P

There total 3 articles about C₂₈H₄₂N₅O₁₄P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-Gly-Wang resin + Fmoc-Leu-OH (35661-60-0) + Fmoc-Glu(OtBu)-OH (71989-18-9) + acetic anhydride (108-24-7) + Fmoc-Thr(tBu)-OH (71989-35-0,138797-71-4) + (S)-3-[4-(Benzyloxy-hydroxy-phosphoryloxy)-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid (191348-16-0) → C28H42N5O14P (1030021-96-5) + Ac-Tyr(PO3H2)-Glu-Thr-Leu-Gly-OH (1030021-84-1)

Guidance literature:

Fmoc-Gly-Wang resin; With piperidine; In N,N-dimethyl-formamide; for 0.0333333h; Automated synthesizer; solid phase reaction;

Fmoc-Leu-OH; With 4-methyl-morpholine; 1-[bis(dimethylamino)methylene]-5-chloro-1H-benzotriazolium-3-oxide tetrafluoroborate; In N,N-dimethyl-formamide; Automated synthesizer; solid phase reaction;

Fmoc-Glu(OtBu)-OH; acetic anhydride; Fmoc-Thr(tBu)-OH; (S)-3-[4-(Benzyloxy-hydroxy-phosphoryloxy)-phenyl]-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid; Automated synthesizer; solid phase reaction;

DOI:10.1039/b718568e

Reference yield:

Fmoc-Gly-Wang resin + Fmoc-Leu-OH (35661-60-0) + Fmoc-Glu(OtBu)-OH (71989-18-9) + acetic anhydride (108-24-7) + Fmoc-Thr(tBu)-OH (71989-35-0,138797-71-4) + Fmoc-Tyr(PO(OMe)2)-OH (127633-36-7,201335-92-4) → C28H42N5O14P (1030021-96-5) + Ac-Tyr(PO3H2)-Glu-Thr-Leu-Gly-OH (1030021-84-1)

Guidance literature:

Fmoc-Gly-Wang resin; With piperidine; In N,N-dimethyl-formamide; for 0.0333333h; Automated synthesizer; solid phase reaction;

Fmoc-Leu-OH; With 4-methyl-morpholine; 1-[bis(dimethylamino)methylene]-5-chloro-1H-benzotriazolium-3-oxide tetrafluoroborate; In N,N-dimethyl-formamide; Automated synthesizer; solid phase reaction;

Fmoc-Glu(OtBu)-OH; acetic anhydride; Fmoc-Thr(tBu)-OH; Fmoc-Tyr(PO(OMe)2)-OH; Automated synthesizer; solid phase reaction;

DOI:10.1039/b718568e

Reference yield:

Fmoc-Gly-Wang resin + Fmoc-Leu-OH (35661-60-0) + Fmoc-Glu(OtBu)-OH (71989-18-9) + acetic anhydride (108-24-7) + Fmoc-Thr(tBu)-OH (71989-35-0,138797-71-4) + (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4(bis(dimethylamino)phosphoryloxy)phenyl)propanoic acid (172611-23-3) → C28H42N5O14P (1030021-96-5) + Ac-Tyr(PO3H2)-Glu-Thr-Leu-Gly-OH (1030021-84-1)

Guidance literature:

Fmoc-Gly-Wang resin; With piperidine; In N,N-dimethyl-formamide; for 0.0333333h; Automated synthesizer; solid phase reaction;

Fmoc-Leu-OH; With 4-methyl-morpholine; 1-[bis(dimethylamino)methylene]-5-chloro-1H-benzotriazolium-3-oxide tetrafluoroborate; In N,N-dimethyl-formamide; Automated synthesizer; solid phase reaction;

Fmoc-Glu(OtBu)-OH; acetic anhydride; Fmoc-Thr(tBu)-OH; (S)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4(bis(dimethylamino)phosphoryloxy)phenyl)propanoic acid; Automated synthesizer; solid phase reaction;

DOI:10.1039/b718568e

upstream raw materials:

Fmoc-Leu-OH

Fmoc-Glu(OtBu)-OH

acetic anhydride

Fmoc-Thr(tBu)-OH