N^a-t-butyloxycarbonyl-L-valyl-O-acetyl-L-tyrosine N-hydroxysuccinimide ester

Base Information

• Chemical Name: N^a-t-butyloxycarbonyl-L-valyl-O-acetyl-L-tyrosine N-hydroxysuccinimide ester
• CAS No.: 108305-08-4
• Molecular Formula: C₂₅H₃₃N₃O₉
• Molecular Weight: 519.552
• Mol file: 108305-08-4.mol

Synonyms:N^a-t-butyloxycarbonyl-L-valyl-O-acetyl-L-tyrosine N-hydroxysuccinimide ester

Chemical Property of N^a-t-butyloxycarbonyl-L-valyl-O-acetyl-L-tyrosine N-hydroxysuccinimide ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^a-t-butyloxycarbonyl-L-valyl-O-acetyl-L-tyrosine N-hydroxysuccinimide ester

There total 3 articles about N^a-t-butyloxycarbonyl-L-valyl-O-acetyl-L-tyrosine N-hydroxysuccinimide ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Nα-t-butyloxycarbonyl-L-valyl-O-acetyl-L-tyrosine (108305-07-3) → Na-t-butyloxycarbonyl-L-valyl-O-acetyl-L-tyrosine N-hydroxysuccinimide ester (108305-08-4)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate;

Reference yield:

Boc-Val-ONSu (3392-12-9) → Na-t-butyloxycarbonyl-L-valyl-O-acetyl-L-tyrosine N-hydroxysuccinimide ester (108305-08-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / 0.5N sodium bicarbonate / tetrahydrofuran / 4 h / Ambient temperature

2: 72 percent / dicyclohexylcarbodiimide / ethyl acetate

With sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethyl acetate;

Reference yield:

O-acetyl-L-tyrosine (6636-22-2,36534-47-1) → Na-t-butyloxycarbonyl-L-valyl-O-acetyl-L-tyrosine N-hydroxysuccinimide ester (108305-08-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / 0.5N sodium bicarbonate / tetrahydrofuran / 4 h / Ambient temperature

2: 72 percent / dicyclohexylcarbodiimide / ethyl acetate

With sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethyl acetate;

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

N^α-t-butyloxycarbonyl-L-valyl-O-acetyl-L-tyrosine

Boc-Val-ONSu

O-acetyl-L-tyrosine

Downstream raw materials:

L-valyl-O-acetyl-L-tyrosine-N-hydroxysuccinimide ester hydrochloride