benzyloxycarbonyl-Gly-Ser-OMe

Base Information

• Chemical Name: benzyloxycarbonyl-Gly-Ser-OMe
• CAS No.: 108849-83-8
• Molecular Formula: C₁₄H₁₈N₂O₆
• Molecular Weight: 310.307
• Mol file: 108849-83-8.mol

Synonyms:benzyloxycarbonyl-Gly-Ser-OMe

Chemical Property of benzyloxycarbonyl-Gly-Ser-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyloxycarbonyl-Gly-Ser-OMe

There total 11 articles about benzyloxycarbonyl-Gly-Ser-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride (5680-80-8) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → N-(N-benzyloxycarbonyl-glycyl)-L-serine methyl ester (108849-83-8,10239-27-7)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide;

DOI:10.1021/ja00094a008

Reference yield: 93.0%

Ser-OMe (2104-89-4,2788-84-3,24184-43-8) + Z-Gly-ONp (1738-86-9) → benzyloxycarbonyl-Gly-Ser-OMe (108849-83-8)

Guidance literature:

With 4-methyl-morpholine; In N,N-dimethyl-formamide; for 48h;

DOI:10.1128/AAC.47.11.3435-3441.2003

Reference yield: 81.0%

(S)-serine methyl ester (2788-84-3) + 2-(((benzyloxy)carbonyl)amino)ethanethioic S-acid (16707-70-3) → N-(N-benzyloxycarbonyl-glycyl)-L-serine methyl ester (108849-83-8,10239-27-7)

Guidance literature:

With isopentyl nitrite; In tetrahydrofuran; at 0 ℃; for 0.0833333h; Darkness;

DOI:10.1021/ol1031393

upstream raw materials:

(S)-serine methyl ester

benzyl (2-azido-2-oxoethyl)carbamate

N-(Benzyloxycarbonyl)glycine

methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

Downstream raw materials:

N-benzyloxycarbonylglycylserine

Z-Gly-Ser-hydrazide

H-Gly-Ser-OMe

Z-Gly-Δ-Ala-OMe