L-SERINE METHYL ESTER

Base Information

• Chemical Name: L-SERINE METHYL ESTER
• CAS No.: 2788-84-3
• Molecular Formula: C4H9 N O3
• Molecular Weight: 119.12
• Hs Code.: 2922509090
• Mol file: 2788-84-3.mol

Synonyms:Serine,methyl ester, L- (6CI,7CI,8CI); (S)-Serine methyl ester; Methyl L-serinate;Methyl serinate; Serine methyl ester

Chemical Property of L-SERINE METHYL ESTER

Chemical Property:

• Melting Point: 161-162℃ (ligroine )
• Boiling Point: 234.7±20.0 °C(Predicted)
• PKA: 11.95±0.10(Predicted)
• PSA: 72.55000
• Density: 1.195±0.06 g/cm3(Predicted)
• LogP: -0.82070

Purity/Quality:

99% ^*data from raw suppliers

(S)-Methyl2-amino-3-hydroxypropanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-SERINE METHYL ESTER

There total 29 articles about L-SERINE METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + D-Serine (312-84-5,83245-15-2) → D-serine methyl ester (2104-89-4,2788-84-3,24184-43-8)

Guidance literature:

With hydrogenchloride; for 18h; Heating;

DOI:10.1016/S0040-4039(00)74203-1

Reference yield: 99.0%

methanol (67-56-1) + L-serin (56-45-1,83245-15-2) → (S)-serine methyl ester (2788-84-3)

Guidance literature:

With acetyl chloride; In methanol;

DOI:10.1016/j.bmc.2014.07.023

Reference yield: 99.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + L-serin (56-45-1,83245-15-2) → (S)-serine methyl ester (2788-84-3)

Guidance literature:

In methanol; diethyl ether; at 20 ℃;

upstream raw materials:

methanol

serin

L-serin

N-tert-butoxycarbonylserine methyl ester

Downstream raw materials:

methyl 1-tritylaziridine-2-carboxylate

benzyloxycarbonyl-Gly-Ser-OMe

3-chloro-DL-alanine methyl ester

serine amide

Refernces

• 1、 Yang, Dan,Chang, Xiao-Wei,Zhang, Dan-Wei,Jiang, Ze-Feng,Song, Ke-Sheng,Zhang, Yu-Hui,Zhu, Nian-Yong,Weng, Lin-Hong,Chen, Min-Qin. "Chiral α-aminoxy acid/achiral cyclopropane α-aminoxy acid unit as a building block for constructing the α N-O helix". . p. 4796 - 4805. Retrieved 2010.
• 2、 Bárta, Pavel,Dole?al, Martin,Horá?ek, Ond?ej,Jand'Ourek, Ond?ej,Janou?ek, Ji?í,Juhás, Martin,Kone?ná, Klára,Ku?era, Radim,Ku?erová, Lucie,Kubí?ek, Vladimír,Kune?, Ji?í,Paterová, Pavla,Zitko, Jan. "N-Pyrazinoyl substituted amino acids as potential antimycobacterial agents-the synthesis and biological evaluation of enantiomers". . . Retrieved 2020/04/09.
• 3、 Bera, Smritilekha,Gupta, Shilpi,Mondal, Dhananjoy. "Nascent-HBr-Catalyzed Removal of Orthogonal Protecting Groups in Aqueous Surfactants". . . Retrieved 2020/02/04.