(2S,4S)-methyl 2-(cyclohexylmethyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate

Base Information

Chemical Name:(2S,4S)-methyl 2-(cyclohexylmethyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate
CAS No.:1251845-92-7
Molecular Formula:C₁₇H₂₆N₂O₄
Molecular Weight:322.404
Hs Code.:

Synonyms:(2S,4S)-methyl 2-(cyclohexylmethyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate

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Chemical Property of (2S,4S)-methyl 2-(cyclohexylmethyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of (2S,4S)-methyl 2-(cyclohexylmethyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate

There total 9 articles about (2S,4S)-methyl 2-(cyclohexylmethyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 2-(cyclohexylmethyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate

: 1251845-91-6
(2R,4R)-methyl 2-(cyclohexylmethyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate

: 1251845-92-7
(2S,4S)-methyl 2-(cyclohexylmethyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate

Guidance literature:: With Chiralcel IC; In n-heptane; isopropyl alcohol; at 40 ℃; Resolution of racemate;

Reference yield:

: cis-methyl 2-(cyclohexylmethyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate

: 1251845-92-7
(2S,4S)-methyl 2-(cyclohexylmethyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate

Guidance literature:: With Chiralpac IC; In n-heptane; isopropyl alcohol; at 40 ℃;
DOI:10.1021/ml400526d

Reference yield:

: 58481-11-1
methyl 2-chloroisonicotinate

: 1251845-92-7
(2S,4S)-methyl 2-(cyclohexylmethyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 18 h / 60 °C

2.1: platinum(IV) oxide; hydrogen / acetic acid / 72 h / 20 °C / 6000.6 Torr

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

4.1: lithium hydroxide; water / tetrahydrofuran / 20 °C / Reflux

5.1: di(2H-imidazol-2-yl)methanone / tetrahydrofuran / 1 h / 5 °C / Inert atmosphere

5.2: 24 h / Inert atmosphere

6.1: sodium hydroxide; water; hydroxylamine hydrochloride / methanol / 0.5 h / -30 °C

7.1: Chiralpac IC / n-heptane; isopropyl alcohol / 40 °C

With platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; water; hydrogen; N-ethyl-N,N-diisopropylamine; sodium hydroxide; lithium hydroxide; di(2H-imidazol-2-yl)methanone; In tetrahydrofuran; methanol; n-heptane; dichloromethane; acetic acid; isopropyl alcohol;
DOI:10.1021/ml400526d