1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl glycinate

Base Information

Chemical Name:1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl glycinate
CAS No.:1197420-13-5
Molecular Formula:C₂₆H₂₂ClF₂N₃O₅S
Molecular Weight:561.994
Hs Code.:

Synonyms:1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl glycinate

Suppliers and Price of 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl glycinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl glycinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl glycinate

There total 10 articles about 1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239489-42-9
C₃₁H₃₀ClF₂N₃O₇S

: 1197420-13-5
1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl glycinate

Guidance literature:: C₃₁H₃₀ClF₂N₃O₇S; With trifluoroacetic acid; In dichloromethane; at 20 ℃;

With sodium carbonate; In dichloromethane; water;

Reference yield:

: 110654-33-6
1,1-difluoro-3-methylenecyclobutane

: 1197420-13-5
1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl glycinate

Guidance literature:: Multi-step reaction with 6 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Cooling with ice

2: sodium dihydrogen phosphate monohydrate / water; acetonitrile / 3.5 h / 130 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 1.5 h / 2585.81 Torr

4: phenol / 0.75 h / 135 - 140 °C

5: 4-pyrrolidin-1-ylpyridine; diisopropyl-carbodiimide / dichloromethane / 0.75 h / Reflux

6: trifluoroacetic acid / dichloromethane / 0.08 h / 20 °C

With sodium dihydrogen phosphate monohydrate; palladium 10% on activated carbon; hydrogen; 4-pyrrolidin-1-ylpyridine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; diisopropyl-carbodiimide; In methanol; dichloromethane; water; acetonitrile; phenol;
DOI:10.1021/acs.jmedchem.6b00676

Reference yield:

: 515142-62-8
methyl 5-(4-chlorophenyl)-3-((dimethylamino)methyleneamino)thiophene-2-carboxylate

: 1197420-13-5
1-((4-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutyl glycinate

Guidance literature:: Multi-step reaction with 3 steps

1: phenol / 0.75 h / 135 - 140 °C

2: 4-pyrrolidin-1-ylpyridine; diisopropyl-carbodiimide / dichloromethane / 0.75 h / Reflux

3: trifluoroacetic acid / dichloromethane / 0.08 h / 20 °C

With 4-pyrrolidin-1-ylpyridine; trifluoroacetic acid; diisopropyl-carbodiimide; In dichloromethane; phenol;
DOI:10.1021/acs.jmedchem.6b00676