N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-fluoro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide trifluoroacetate

Base Information

Chemical Name:N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-fluoro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide trifluoroacetate
CAS No.:1047645-87-3
Molecular Formula:C₂HF₃O₂*C₁₉H₁₇ClF₄N₄OS
Molecular Weight:574.907
Hs Code.:

N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-fluoro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide trifluoroacetate

Synonyms:N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-fluoro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide trifluoroacetate

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Chemical Property of N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-fluoro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide trifluoroacetate

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Technology Process of N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-fluoro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide trifluoroacetate

There total 12 articles about N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-fluoro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35475-03-7
methyl 5-chloro-2-thiophenecarboxylate

: 1047645-87-3
N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-fluoro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 11 steps

1.1: N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride / acetic acid / 48 h / 70 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 15 h / 80 °C

3.1: N-chloro-succinimide / tetrahydrofuran / 4 h / 70 °C

3.2: 2 h

4.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 12 h / 20 °C

5.1: hydrazine / tetrahydrofuran; methanol / 24 h / 20 °C

6.1: hydrogenchloride / 1,4-dioxane / 0.08 h

7.1: Selectfluor / water; acetonitrile / 12 h / 70 °C

8.1: sodium hydroxide / tetrahydrofuran; water / 1 h / 70 °C

8.2: acid / pH 4

9.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 12 h / 25 °C

10.1: hydrazine / tetrahydrofuran; methanol / 48 h / 25 °C

With hydrogenchloride; sodium hydroxide; N-chloro-succinimide; potassium carbonate; N,N,N-trimethylbenzenemethanaminium dichloroiodate; Selectfluor; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; zinc(II) chloride; hydrazine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetic acid; acetonitrile;

Reference yield:

: 24065-33-6
5-Chlorothiophene-2-carboxylic acid

: 1047645-87-3
N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-fluoro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 12 steps

1.1: sulfuric acid / 12 - 20 h / 50 - 55 °C

2.1: aluminum (III) chloride; bromine / chloroform / 6 h / 25 °C

3.1: potassium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 1.5 h / 75 °C

4.1: N-chloro-succinimide / tetrahydrofuran / 4 h / 70 °C

4.2: 2 h

5.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 12 h / 20 °C

6.1: hydrazine / tetrahydrofuran; methanol / 24 h / 20 °C

7.1: hydrogenchloride / 1,4-dioxane / 0.08 h

8.1: Selectfluor / water; acetonitrile / 12 h / 70 °C

9.1: sodium hydroxide / tetrahydrofuran; water / 1 h / 70 °C

9.2: acid / pH 4

10.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 12 h / 25 °C

11.1: hydrazine / tetrahydrofuran; methanol / 48 h / 25 °C

With hydrogenchloride; aluminum (III) chloride; sodium hydroxide; N-chloro-succinimide; sulfuric acid; bromine; potassium carbonate; Selectfluor; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; hydrazine; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; chloroform; water; acetonitrile;

Reference yield:

: 1047630-72-7
methyl 4-bromo-5-chlorothiophene-2-carboxylate

: 1047645-87-3
N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-fluoro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide trifluoroacetate

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane; water / 1.5 h / 75 °C

2.1: N-chloro-succinimide / tetrahydrofuran / 4 h / 70 °C

2.2: 2 h

3.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 12 h / 20 °C

4.1: hydrazine / tetrahydrofuran; methanol / 24 h / 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 0.08 h

6.1: Selectfluor / water; acetonitrile / 12 h / 70 °C

7.1: sodium hydroxide / tetrahydrofuran; water / 1 h / 70 °C

7.2: acid / pH 4

8.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 12 h / 25 °C

9.1: hydrazine / tetrahydrofuran; methanol / 48 h / 25 °C

With hydrogenchloride; sodium hydroxide; N-chloro-succinimide; potassium carbonate; Selectfluor; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; hydrazine; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;