Welcome to LookChem.com Sign In|Join Free

CAS

  • or

35475-03-7

Post Buying Request

35475-03-7 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

35475-03-7 Usage

General Description

Methyl-5-chlorothiophene-2-carboxylate is a chemical compound with the molecular formula C8H7ClO2S. It is a chlorinated ester derivative of thiophene carboxylic acid, and its structure consists of a thiophene ring with a chloro substituent at the 5-position and a carboxymethyl ester group at the 2-position. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is known for its strong and distinct odor, and it is considered to be a hazardous substance due to its potential for causing irritation to the respiratory system, skin, and eyes. Therefore, proper handling and safety precautions are necessary when working with this compound.

Check Digit Verification of cas no

The CAS Registry Mumber 35475-03-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,4,7 and 5 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 35475-03:
(7*3)+(6*5)+(5*4)+(4*7)+(3*5)+(2*0)+(1*3)=117
117 % 10 = 7
So 35475-03-7 is a valid CAS Registry Number.

35475-03-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name methyl 5-chlorothiophene-2-carboxylate

1.2 Other means of identification

Product number -
Other names QC-5846

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:35475-03-7 SDS

35475-03-7Relevant articles and documents

Discovery of 3-(thiophen/thiazole-2-ylthio)pyridine derivatives as multitarget anticancer agents

Zhang, Jiankang,Xi, Jianjun,He, Ruoyu,Zhuang, Rangxiao,Kong, Limin,Fu, Liping,Zhao, Yanmei,Zhang, Chong,Zeng, Linghui,Lu, Jingyi,Tao, Rujia,Liu, Zhengmengtong,Zhu, Huajian,Liu, Shourong

, p. 1633 - 1647 (2019)

A series of novel 3-(thiophen/thiazole-2-ylthio)pyridine derivatives were designed and synthesized as IGF-1R tyrosine kinase inhibitors. All the target compounds were tested for their IGF-1R kinase inhibitory activities and cytotoxicities against five cancer cell lines (K562, Hep-G2, HCT-116, WSU-DLCL2, and A549). Although all these compounds exhibited moderate to potent cancer cell proliferation inhibitory activities (the most potent compound 43 showed IC50 value of 1.3 ± 0.9 μM against WSU-DLCL2 cell line), IGF-1R inhibition were not observed. In order to identify the exact target of these analogues, selected compounds were further screened for various kinases. The results indicated that this series of compounds may exert their anticancer activities through inhibiting various kinases including FGFR 3, EGFR, JAK, and RON. In addition, cell cycle analysis of compound 43 on Hep-G2 cells showed cell cycle arrest at G1/G0 phase. All the experiments validated the potential of 3-(thiophen/thiazole-2-ylthio)pyridine analogues as multi-target anticancer agents.

Ag(I)-Catalyzed C-H Carboxylation of Thiophene Derivatives

Lee, Mijung,Hwang, Young Kyu,Kwak, Jaesung

supporting information, p. 3136 - 3144 (2021/09/30)

CO2utilization is an attractive aspect as it allows the direct conversion of CO2into valuable chemicals. In this regard, direct incorporation of CO2into the C-H bond of heteroaromatic compounds is important due to the ubiquitous structural motifs of the heteroaromatic carboxylic acids. Herein, we report the Ag-catalyzed C-H carboxylation of thiophene derivatives. This new catalytic system involving a phosphine ligand and lithiumtert-butoxide enables the direct carboxylation of thiophenes under mild reaction conditions. Experimental studies revealed that the use oftert-butyl alkoxide is critical for the exergonic formation of an arylsilver intermediate, and the results were further supported by density functional theory calculations.

BUMETANIDE DERIVATIVES FOR THE THERAPY OF HYPERHIDROSIS

-

Page/Page column 168, (2019/10/30)

The present invention relates to bumetanide derivatives of formula (I) as well as pharmaceutical compositions comprising these compounds for use in the treatment or prevention of diseases/disorders involving Na+- K+- 2CI- - cotransporters (NKCCs), and particularly for use in the treatment or prevention of hyperhidrosis.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 35475-03-7