Methyl-5-chlorothiophene-2-carboxylate

Base Information

• Chemical Name: Methyl-5-chlorothiophene-2-carboxylate
• CAS No.: 35475-03-7
• Molecular Formula: C6H5ClO2S
• Molecular Weight: 176.624
• Hs Code.: 2934999090
• Mol file: 35475-03-7.mol

Synonyms:QC-5846;5-chlorothiophene-2-carboxylic acid methyl ester;Methyl 5-chloro-2-thiophenecarboxylate;methyl 5-chlorothiophene-2-carboxylic acid;5-Chlor-thiophen-2-carbonsaeure-methylester;2-chloro-5-methoxycarbonylthiophene;

Chemical Property of Methyl-5-chlorothiophene-2-carboxylate

Chemical Property:

• Melting Point: 16.5-18℃
• Refractive Index: 1.56
• Boiling Point: 95-97℃ (7 Torr)
• PSA: 54.54000
• Density: 1.371±0.06 g/cm3(Predicted)
• LogP: 2.18810
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: Chloroform (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl 5-Chlorothiophene-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl-5-chlorothiophene-2-carboxylate

There total 15 articles about Methyl-5-chlorothiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 5-Chlorothiophene-2-carboxylic acid (24065-33-6) → methyl 5-chloro-2-thiophenecarboxylate (35475-03-7)

Guidance literature:

With sulfuric acid; at 50 - 55 ℃; for 12 - 20h;

Reference yield: 80.0%

2-thienyl chloride (96-43-5) + methanol (67-56-1) + carbon tetrabromide (558-13-4) → methyl 5-chloro-2-thiophenecarboxylate (35475-03-7)

Guidance literature:

With tris(bipyridine)ruthenium(II) dichloride hexahydrate; potassium carbonate; at 20 ℃; for 24h; regioselective reaction; Inert atmosphere; Irradiation;

DOI:10.1021/acs.joc.9b00942

Reference yield: 77.0%

2-bromothiophene (1003-09-4) + methanol (67-56-1) + tetrachloromethane (56-23-5) → methyl 5-chloro-2-thiophenecarboxylate (35475-03-7) + 5-bromo-2-thiophenecarboxylic acid methyl ester (62224-19-5)

Guidance literature:

With molybdenum hexacarbonyl; at 150 ℃; for 6h; Inert atmosphere; Autoclave;

DOI:10.1134/S0965544108060121

upstream raw materials:

methanol

5-Chlorothiophene-2-carboxylic acid

thiophene-2-carboxylic acid methyl ester

5-chlorothiophene-2-carbonyl chloride

Downstream raw materials:

5-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylic acid methyl ester

5-chlorothiophene-2-carboxamide

5-chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide thiocyanate

5-chloro-N-((1-(4-(2-oxopyridin-1(2H)-yl)phenyl)-1H-imidazol-4-yl)methyl)thiophene-2-carboxamide phosphate

Refernces

• 1、 Elghamry, Ibrahim,El-Ayaan, Usama,Youssef, Magdy M.,Al-Shihry, Shar,Letzel, Matthias,Mattay, Jochen. "Photochemical and DNA degradation studies on tenoxicam, lornoxicam, and their photolysis products". . p. 257 - 262. Retrieved 2017.
• 2、 -. "BUMETANIDE DERIVATIVES FOR THE THERAPY OF HYPERHIDROSIS". Page/Page column 168. . Retrieved 2019/10/30.