2-[(1R,3R,E)-3-{[(tert-butyldimethylsilyl)oxy]methyl}-2-{[dimethyl(phenyl)silyl]methylene}-3-methylcyclopentyl]propan-2-ol

Base Information

Chemical Name:2-[(1R,3R,E)-3-{[(tert-butyldimethylsilyl)oxy]methyl}-2-{[dimethyl(phenyl)silyl]methylene}-3-methylcyclopentyl]propan-2-ol
CAS No.:1414855-05-2
Molecular Formula:C₂₅H₄₄O₂Si₂
Molecular Weight:432.794
Hs Code.:

Synonyms:2-[(1R,3R,E)-3-{[(tert-butyldimethylsilyl)oxy]methyl}-2-{[dimethyl(phenyl)silyl]methylene}-3-methylcyclopentyl]propan-2-ol

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Chemical Property of 2-[(1R,3R,E)-3-{[(tert-butyldimethylsilyl)oxy]methyl}-2-{[dimethyl(phenyl)silyl]methylene}-3-methylcyclopentyl]propan-2-ol

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Technology Process of 2-[(1R,3R,E)-3-{[(tert-butyldimethylsilyl)oxy]methyl}-2-{[dimethyl(phenyl)silyl]methylene}-3-methylcyclopentyl]propan-2-ol

There total 7 articles about 2-[(1R,3R,E)-3-{[(tert-butyldimethylsilyl)oxy]methyl}-2-{[dimethyl(phenyl)silyl]methylene}-3-methylcyclopentyl]propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 3839-31-4
dimethyl(phenyl)silyl lithium

: tert-butyl{[(R)-2-{2-[(R)-3,3-dimethyloxiran-2-yl]ethyl}-2-methylbut-3-yn-1-yl]oxy}dimethylsilane

: 1414855-05-2
2-[(1R,3R,E)-3-{[(tert-butyldimethylsilyl)oxy]methyl}-2-{[dimethyl(phenyl)silyl]methylene}-3-methylcyclopentyl]propan-2-ol

Guidance literature:: dimethyl(phenyl)silyl lithium; With copper(l) cyanide; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

tert-butyl{[(R)-2-{2-[(R)-3,3-dimethyloxiran-2-yl]ethyl}-2-methylbut-3-yn-1-yl]oxy}dimethylsilane; In tetrahydrofuran; at -78 - 0 ℃; Inert atmosphere;

With boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 ℃; for 12h; Inert atmosphere;
DOI:10.1055/s-0032-1316589

Reference yield: 65.0%

: 3839-31-4
dimethyl(phenyl)silyl lithium

: 1414855-04-1
tert-butyl{[(R)-2-{2-[(R)-3,3-dimethyloxiran-2-yl]ethyl}-2-methylbut-3-yn-1-yl]oxy}dimethylsilane

: 1414855-05-2
2-[(1R,3R,E)-3-{[(tert-butyldimethylsilyl)oxy]methyl}-2-{[dimethyl(phenyl)silyl]methylene}-3-methylcyclopentyl]propan-2-ol

: C₂₅H₄₄O₂Si₂

: 1422986-25-1
C₁₉H₃₈O₂Si₂

Guidance literature:: With boron trifluoride diethyl etherate; copper(l) cyanide; In tetrahydrofuran; at -78 - 0 ℃; for 18h;
DOI:10.1055/s-0032-1316589

Reference yield: 64.0%

: 3839-31-4
dimethyl(phenyl)silyl lithium

: 1414855-04-1
tert-butyl{[(R)-2-{2-[(R)-3,3-dimethyloxiran-2-yl]ethyl}-2-methylbut-3-yn-1-yl]oxy}dimethylsilane

: 1414855-05-2
2-[(1R,3R,E)-3-{[(tert-butyldimethylsilyl)oxy]methyl}-2-{[dimethyl(phenyl)silyl]methylene}-3-methylcyclopentyl]propan-2-ol

: C₂₅H₄₄O₂Si₂

Guidance literature:: With boron trifluoride diethyl etherate; copper(l) cyanide; In tetrahydrofuran; at -78 - 0 ℃; for 6h;
DOI:10.1055/s-0032-1316589