6-(3,3-dimethoxypropyl)-4-phenyl-2-pyrazol-1-yl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester

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Chemical Name:6-(3,3-dimethoxypropyl)-4-phenyl-2-pyrazol-1-yl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester
CAS No.:911857-37-9
Molecular Formula:C₂₆H₃₄N₄O₆
Molecular Weight:498.579
Hs Code.:

Synonyms:6-(3,3-dimethoxypropyl)-4-phenyl-2-pyrazol-1-yl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester

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Chemical Property of 6-(3,3-dimethoxypropyl)-4-phenyl-2-pyrazol-1-yl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester

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Technology Process of 6-(3,3-dimethoxypropyl)-4-phenyl-2-pyrazol-1-yl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester

There total 3 articles about 6-(3,3-dimethoxypropyl)-4-phenyl-2-pyrazol-1-yl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 911857-32-4
4-(3,3-dimethoxypropyl)-6-phenyl-2-pyrazol-1-yl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 911857-37-9
6-(3,3-dimethoxypropyl)-4-phenyl-2-pyrazol-1-yl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester

Guidance literature:: With dmap; In acetonitrile; at 20 ℃; for 12h;
DOI:10.1021/jo061199m

Reference yield:

: 56681-97-1
4,4-dimethoxybutanal

: 911857-37-9
6-(3,3-dimethoxypropyl)-4-phenyl-2-pyrazol-1-yl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / NaHCO₃ / dimethylformamide / 48 h / 70 °C

2: 88 percent / DMAP / acetonitrile / 12 h / 20 °C

With dmap; sodium hydrogencarbonate; In N,N-dimethyl-formamide; acetonitrile; 1: Biginelli reaction;
DOI:10.1021/jo061199m

Reference yield:

: 94-02-0
ethyl 3-oxo-3-phenylpropionate

: 911857-37-9
6-(3,3-dimethoxypropyl)-4-phenyl-2-pyrazol-1-yl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / NaHCO₃ / dimethylformamide / 48 h / 70 °C

2: 88 percent / DMAP / acetonitrile / 12 h / 20 °C

With dmap; sodium hydrogencarbonate; In N,N-dimethyl-formamide; acetonitrile; 1: Biginelli reaction;
DOI:10.1021/jo061199m