4-(3,3-dimethoxypropyl)-6-phenyl-2-pyrazol-1-yl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-(3,3-dimethoxypropyl)-6-phenyl-2-pyrazol-1-yl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester
• CAS No.: 911857-32-4
• Molecular Formula: C₂₁H₂₆N₄O₄
• Molecular Weight: 398.462
• Mol file: 911857-32-4.mol

Synonyms:4-(3,3-dimethoxypropyl)-6-phenyl-2-pyrazol-1-yl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

Chemical Property of 4-(3,3-dimethoxypropyl)-6-phenyl-2-pyrazol-1-yl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-(3,3-dimethoxypropyl)-6-phenyl-2-pyrazol-1-yl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester

There total 1 articles about 4-(3,3-dimethoxypropyl)-6-phenyl-2-pyrazol-1-yl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4,4-dimethoxybutanal (56681-97-1) + ethyl 3-oxo-3-phenylpropionate (94-02-0) + 1H-pyrazole-1-carboximidamide hydrochloride (4023-02-3) → 4-(3,3-dimethoxypropyl)-6-phenyl-2-pyrazol-1-yl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester (911857-32-4)

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 70 ℃; for 48h;

DOI:10.1021/jo061199m

Reference yield: 88.0%

4-(3,3-dimethoxypropyl)-6-phenyl-2-pyrazol-1-yl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester (911857-32-4) + di-tert-butyl dicarbonate (24424-99-5) → 6-(3,3-dimethoxypropyl)-4-phenyl-2-pyrazol-1-yl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester (911857-37-9)

Guidance literature:

With dmap; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1021/jo061199m

Reference yield:

4-(3,3-dimethoxypropyl)-6-phenyl-2-pyrazol-1-yl-1,4-dihydropyrimidine-5-carboxylic acid ethyl ester (911857-32-4) → Trifluoro-acetate(2aR,8aR)-3-allyloxycarbonyl-8-ethoxycarbonyl-4-methyl-7-phenyl-1,2,2a,5,6,8a-hexahydro-5,6,8b-triaza-acenaphthylen-8b-ylium;

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / DMAP / acetonitrile / 12 h / 20 °C

2: 67 percent / NH₄Cl; NH₃ / tetrahydrofuran / 12 h / 70 °C

3: CH₂Cl₂ / 1 h

4: 156 mg / morpholinium acetate; Na₂SO₄ / 2,2,2-trifluoro-ethanol / 72 h / 70 °C

With dmap; ammonia; morpholinium acetate; ammonium chloride; sodium sulfate; In tetrahydrofuran; dichloromethane; 2,2,2-trifluoroethanol; acetonitrile;

DOI:10.1021/jo061199m

upstream raw materials:

4,4-dimethoxybutanal

ethyl 3-oxo-3-phenylpropionate

1H-pyrazole-1-carboximidamide hydrochloride

Downstream raw materials:

6-(3,3-dimethoxypropyl)-4-phenyl-2-pyrazol-1-yl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester

2-amino-6-(3,3-dimethoxypropyl)-4-phenyl-6H-pyrimidine-1,5-dicarboxylic acid 1-tert-butyl ester 5-ethyl ester