1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-pyrrolidone

Base Information

Chemical Name:1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-pyrrolidone
CAS No.:99707-37-6
Molecular Formula:C₁₈H₂₄N₂O₅
Molecular Weight:348.399
Hs Code.:

Synonyms:1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-pyrrolidone

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Chemical Property of 1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-pyrrolidone

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Technology Process of 1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-pyrrolidone

There total 2 articles about 1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-pyrrolidone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 81867-37-0
benzyl iodoacetate

: 99780-97-9
(2-oxo-pyrrolidin-3-(S)-yl)-carbamic acid tert-butyl ester

: 99707-37-6
1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-pyrrolidone

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; for 3.5h; Ambient temperature;
DOI:10.1021/jm00152a014

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 99707-37-6
1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-pyrrolidone

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / triethylamine / CH₂Cl₂ / 3 h / Ambient temperature

2: 46 percent / NaH / dimethylformamide; tetrahydrofuran / 3.5 h / Ambient temperature

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00152a014

Reference yield:

: 99707-37-6
1-<(benzyloxycarbonyl)methyl>-3-<(tert-butoxycarbonyl)amino>-2-pyrrolidone

: 77591-07-2,179605-47-1,179605-48-2
(+/-)-1-(carboxymethyl)-3-amino-2-pyrrolidone

Guidance literature:: Multi-step reaction with 2 steps

1: 2 h / Ambient temperature

2: H₂ / 10percent Pd/C / methanol; H₂O / 2068.6 Torr

With hydrogen; palladium on activated charcoal; In methanol; water;
DOI:10.1021/jm00152a014