(5R)-6-(difluoromethylidene)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Base Information

Chemical Name:(5R)-6-(difluoromethylidene)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine
CAS No.:1443259-23-1
Molecular Formula:C₁₈H₁₇F₃N₄O₂
Molecular Weight:378.354
Hs Code.:

Synonyms:(5R)-6-(difluoromethylidene)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

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Chemical Property of (5R)-6-(difluoromethylidene)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

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Technology Process of (5R)-6-(difluoromethylidene)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

There total 1 articles about (5R)-6-(difluoromethylidene)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 24100-18-3
2-bromo-3-methoxypyridine

: 1443035-47-9
(5R)-5-(5-amino-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

: 1443259-23-1
(5R)-6-(difluoromethylidene)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Guidance literature:: With sulfuric acid; In isopropyl alcohol; at 80 ℃; for 72h;

Reference yield: 32.0%

: 1443259-23-1
(5R)-6-(difluoromethylidene)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

: 1443259-24-2
(5R)-6-(difluoromethyl)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Guidance literature:: With thiophene; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 16h; under 760.051 Torr;

Reference yield: 32.0%

: 1443259-23-1
(5R)-6-(difluoromethylidene)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

: (5R,6RS)-6-(difluoromethyl)-5-{2-fluoro-5-[(3-methoxypyridin-2-yl)amino]phenyl}-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Guidance literature:: With thiophene; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 16h; under 760.051 Torr;