(5R)-5-(5-amino-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Base Information

Chemical Name:(5R)-5-(5-amino-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine
CAS No.:1443035-47-9
Molecular Formula:C₁₂H₁₂F₃N₃O
Molecular Weight:271.242
Hs Code.:

Synonyms:(5R)-5-(5-amino-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

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Chemical Property of (5R)-5-(5-amino-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

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Technology Process of (5R)-5-(5-amino-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

There total 13 articles about (5R)-5-(5-amino-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1443035-45-7
(5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

: 1443035-47-9
(5R)-5-(5-amino-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Guidance literature:: (5R)-5-(5-bromo-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine; With copper(l) iodide; sodium azide; sodium carbonate; N,N`-dimethylethylenediamine; In dimethyl sulfoxide; at 110 ℃; for 3h;

With ammonia; In methanol;

Reference yield: 52.0%

: 1443035-47-9
(5R)-5-(5-amino-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Guidance literature:: With copper(l) iodide; sodium azide; sodium carbonate; N,N`-dimethylethylenediamine; In dimethyl sulfoxide; at 110 ℃; for 4h;

Reference yield:

: 1443035-39-9
(5R)-5-(5-bromo-2-fluorophenyl)-6-chloro-5-methyl-6-(trifluoromethyl)morpholin-3-one

: 1443035-47-9
(5R)-5-(5-amino-2-fluorophenyl)-6-(difluoromethylene)-5-methyl-5,6-dihydro-2H-1,4-oxazin-3-amine

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid; zinc-copper couple / 16 h / 20 °C

2: tetraphosphorus decasulfide / tetrahydrofuran / 1.5 h / 20 - 70 °C

3: ammonia / methanol / 2 h / 80 °C

4: sodium azide; copper(l) iodide; sodium carbonate; N,N`-dimethylethylenediamine / dimethyl sulfoxide / 3 h / 110 °C

With copper(l) iodide; sodium azide; tetraphosphorus decasulfide; zinc-copper couple; ammonia; sodium carbonate; acetic acid; N,N`-dimethylethylenediamine; In tetrahydrofuran; methanol; dimethyl sulfoxide;