(2R,3S)-3-Amino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester hydrochloride

Base Information

Chemical Name:(2R,3S)-3-Amino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester hydrochloride
CAS No.:1071522-01-4
Molecular Formula:C₁₀H₁₇NO₂*ClH
Molecular Weight:219.711
Hs Code.:

Synonyms:(2R,3S)-3-Amino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester hydrochloride

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Chemical Property of (2R,3S)-3-Amino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester hydrochloride

Chemical Property:

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Technology Process of (2R,3S)-3-Amino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester hydrochloride

There total 5 articles about (2R,3S)-3-Amino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1071521-98-6
(2R,3S)-3-benzyloxycarbonylamino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester

: 1071522-01-4,1630906-99-8
(2R,3S)-3-Amino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester hydrochloride

Guidance literature:: (2R,3S)-3-benzyloxycarbonylamino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester; With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 25 ℃; for 16h;

With hydrogenchloride; In 1,4-dioxane; diethyl ether;

Reference yield:

: 26843-47-0
bicyclo[2.2.2]octane-2-endo,3-endo-dicarboxylic acid anhydride

: 1071522-01-4,1630906-99-8
(2R,3S)-3-Amino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: Quinine / ethyl acetate; toluene; tetrachloromethane; methanol

2: triethylamine; sodium azide; benzyl alcohol / dichloromethane; ethyl acetate; benzene; water; tetrahydrofuran

3: hydrogenchloride / palladium / ethyl acetate; 1,4-dioxane; diethyl ether

With hydrogenchloride; sodium azide; triethylamine; benzyl alcohol; Quinine; palladium; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; diethyl ether; dichloromethane; water; ethyl acetate; toluene; benzene;

Reference yield:

: 6708-37-8,85081-13-6,85081-14-7
bicyclo[2.2.2]oct-5-ene-2,3-dicarboxylic anhydride

: 1071522-01-4,1630906-99-8
(2R,3S)-3-Amino-bicyclo[2.2.2]octane-2-carboxylic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: palladium / ethyl acetate

2: Quinine / ethyl acetate; toluene; tetrachloromethane; methanol

3: triethylamine; sodium azide; benzyl alcohol / dichloromethane; ethyl acetate; benzene; water; tetrahydrofuran

4: hydrogenchloride / palladium / ethyl acetate; 1,4-dioxane; diethyl ether

With hydrogenchloride; sodium azide; triethylamine; benzyl alcohol; Quinine; palladium; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; diethyl ether; dichloromethane; water; ethyl acetate; toluene; benzene;