4,4-dimethyl-6-(cyclohexylmethyl)tetrahydro-1,2,3-oxathiazine-2,2-dioxide

Base Information

Chemical Name:4,4-dimethyl-6-(cyclohexylmethyl)tetrahydro-1,2,3-oxathiazine-2,2-dioxide
CAS No.:1151967-65-5
Molecular Formula:C₁₂H₂₃NO₃S
Molecular Weight:261.386
Hs Code.:

Synonyms:4,4-dimethyl-6-(cyclohexylmethyl)tetrahydro-1,2,3-oxathiazine-2,2-dioxide

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Chemical Property of 4,4-dimethyl-6-(cyclohexylmethyl)tetrahydro-1,2,3-oxathiazine-2,2-dioxide

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Technology Process of 4,4-dimethyl-6-(cyclohexylmethyl)tetrahydro-1,2,3-oxathiazine-2,2-dioxide

There total 4 articles about 4,4-dimethyl-6-(cyclohexylmethyl)tetrahydro-1,2,3-oxathiazine-2,2-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1151967-55-3
1-cyclohexyl-4-methylpentan-2-yl sulfamate

: 1151967-65-5
4,4-dimethyl-6-(cyclohexylmethyl)tetrahydro-1,2,3-oxathiazine-2,2-dioxide

: 1151967-63-3
4-(2-methylpropyl)-3-oxa-2-thia-1-azaspiro[5.5]undecane-2,2-dioxide

Guidance literature:: With iodosylbenzene; silver trifluoromethanesulfonate; 4,4'-di-tert-butyl-2,2'-bipyridine; In dichloromethane; at 20 ℃; for 0.5h; regioselective reaction; Molecular sieve;
DOI:10.1021/ja5094309

Reference yield:

: 1186428-76-1
1-cyclohexyl-4-methylpentan-2-ol

: 1151967-65-5
4,4-dimethyl-6-(cyclohexylmethyl)tetrahydro-1,2,3-oxathiazine-2,2-dioxide

: 1151967-63-3
4-(2-methylpropyl)-3-oxa-2-thia-1-azaspiro[5.5]undecane-2,2-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: formic acid; isocyanate de chlorosulfonyle / N,N-dimethyl acetamide; acetonitrile / 1 h / 0 - 20 °C

2: silver trifluoromethanesulfonate; tris[(2-pyridylmethyl)amine]; iodosylbenzene / dichloromethane / 0.5 h / 20 °C / Molecular sieve

With formic acid; isocyanate de chlorosulfonyle; iodosylbenzene; silver trifluoromethanesulfonate; tris[(2-pyridylmethyl)amine]; In dichloromethane; N,N-dimethyl acetamide; acetonitrile;
DOI:10.1021/ja5094309

Reference yield:

: 590-86-3
isovaleraldehyde

: 1151967-65-5
4,4-dimethyl-6-(cyclohexylmethyl)tetrahydro-1,2,3-oxathiazine-2,2-dioxide

: 1151967-63-3
4-(2-methylpropyl)-3-oxa-2-thia-1-azaspiro[5.5]undecane-2,2-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1.1: magnesium / diethyl ether / 0.5 h / Reflux

1.2: 1 h / -78 °C

2.1: formic acid; isocyanate de chlorosulfonyle / N,N-dimethyl acetamide; acetonitrile / 1 h / 0 - 20 °C

3.1: silver trifluoromethanesulfonate; tris[(2-pyridylmethyl)amine]; iodosylbenzene / dichloromethane / 0.5 h / 20 °C / Molecular sieve

With formic acid; isocyanate de chlorosulfonyle; iodosylbenzene; silver trifluoromethanesulfonate; tris[(2-pyridylmethyl)amine]; magnesium; In diethyl ether; dichloromethane; N,N-dimethyl acetamide; acetonitrile;
DOI:10.1021/ja5094309