cis-2-methyl-propane-2-sulfinic acid {1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-2-fluoro-ethyl}-amide

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Chemical Name:cis-2-methyl-propane-2-sulfinic acid {1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-2-fluoro-ethyl}-amide
CAS No.:1202008-66-9
Molecular Formula:C₂₄H₄₁F₂NO₂SSi
Molecular Weight:473.743
Hs Code.:

Synonyms:cis-2-methyl-propane-2-sulfinic acid {1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-2-fluoro-ethyl}-amide

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Chemical Property of cis-2-methyl-propane-2-sulfinic acid {1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-2-fluoro-ethyl}-amide

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Technology Process of cis-2-methyl-propane-2-sulfinic acid {1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-2-fluoro-ethyl}-amide

There total 8 articles about cis-2-methyl-propane-2-sulfinic acid {1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-2-fluoro-ethyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202176-63-3
cis-2-methyl-propane-2-sulfinic acid {2-benzenesulfonyl-1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-2-fluoro-ethyl}-amide

: 1202008-66-9
cis-2-methyl-propane-2-sulfinic acid {1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-2-fluoro-ethyl}-amide

Guidance literature:: With sodium dihydrogenphosphate; sodium amalgam; In methanol; at 0 - 20 ℃; for 40h;

Reference yield:

: 1202007-00-8
cis-4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexane-carbonitrile

: 1202008-66-9
cis-2-methyl-propane-2-sulfinic acid {1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-2-fluoro-ethyl}-amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diisobutylaluminium hydride / dichloromethane / 1.33 h / -70 °C

1.2: 2 h / 20 °C

2.1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / Reflux

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

4.1: sodium dihydrogenphosphate; sodium amalgam / methanol / 40 h / 0 - 20 °C

With titanium(IV) tetraethanolate; sodium dihydrogenphosphate; sodium amalgam; diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 56326-95-5
methyl 5-cyano-5-(4-fluorophenyl)-2-oxocyclohexanecarboxylate

: 1202008-66-9
cis-2-methyl-propane-2-sulfinic acid {1-[4-(tert-butyl-dimethyl-silanyloxy)-1-(4-fluoro-phenyl)-cyclohexyl]-2-fluoro-ethyl}-amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / ethanol; water / 40 h / Reflux

2.1: sodium tetrahydroborate / ethanol / -20 - 20 °C

3.1: 2,6-dimethylpyridine / dichloromethane / 0 - 20 °C

4.1: diisobutylaluminium hydride / dichloromethane / 1.33 h / -70 °C

4.2: 2 h / 20 °C

5.1: titanium(IV) tetraethanolate / tetrahydrofuran / 16 h / Reflux

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

7.1: sodium dihydrogenphosphate; sodium amalgam / methanol / 40 h / 0 - 20 °C

With 2,6-dimethylpyridine; hydrogenchloride; titanium(IV) tetraethanolate; sodium tetrahydroborate; sodium dihydrogenphosphate; sodium amalgam; diisobutylaluminium hydride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;