(S)-2-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxamido)-6-fluorobenzoic acid

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Chemical Name:(S)-2-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxamido)-6-fluorobenzoic acid
CAS No.:1489278-00-3
Molecular Formula:C₄₃H₃₅FN₄O₅S
Molecular Weight:738.839
Hs Code.:

Synonyms:(S)-2-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxamido)-6-fluorobenzoic acid

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Chemical Property of (S)-2-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxamido)-6-fluorobenzoic acid

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Technology Process of (S)-2-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxamido)-6-fluorobenzoic acid

There total 8 articles about (S)-2-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxamido)-6-fluorobenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₄H₃₇FN₄O₅S

: 1489278-00-3
(S)-2-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxamido)-6-fluorobenzoic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 50 ℃; for 2h;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 1489279-29-9
(S)-2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylic acid

: 1489278-00-3
(S)-2-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxamido)-6-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: HATU; 4-methyl-morpholine / dichloromethane / 20 °C

2: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 2 h / 50 °C

With 4-methyl-morpholine; lithium hydroxide monohydrate; HATU; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 1489279-24-4
(S)-ethyl 2-(1-(3-(1H-Indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylate

: 1489278-00-3
(S)-2-(2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxamido)-6-fluorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; methanol / water / 20 °C

2: HATU; 4-methyl-morpholine / dichloromethane / 20 °C

3: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 2 h / 50 °C

With 4-methyl-morpholine; methanol; lithium hydroxide monohydrate; potassium carbonate; HATU; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2013.09.017