(S)-2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylic acid

Base Information

Chemical Name:(S)-2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylic acid
CAS No.:1489279-29-9
Molecular Formula:C₃₆H₃₁N₃O₄S
Molecular Weight:601.726
Hs Code.:

Synonyms:(S)-2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylic acid

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Chemical Property of (S)-2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylic acid

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Technology Process of (S)-2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylic acid

There total 6 articles about (S)-2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1489279-24-4
(S)-ethyl 2-(1-(3-(1H-Indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylate

: 1489279-29-9
(S)-2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylic acid

Guidance literature:: With methanol; potassium carbonate; In water; at 20 ℃;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 1489279-29-9
(S)-2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 2 h / 20 °C

2: Lawessons reagent / tetrahydrofuran / 2 h / 65 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 20 °C

5: potassium carbonate; methanol / water / 20 °C

With Lawessons reagent; methanol; dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 1489279-19-7
C₂₇H₂₆N₂O₃S

: 1489279-29-9
(S)-2-(1-(3-(1H-indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 20 °C

2: potassium carbonate; methanol / water / 20 °C

With methanol; dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; water;
DOI:10.1016/j.ejmech.2013.09.017