(S)-ethyl 2-(1-(3-(1H-Indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylate

Base Information

Chemical Name:(S)-ethyl 2-(1-(3-(1H-Indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylate
CAS No.:1489279-24-4
Molecular Formula:C₃₈H₃₅N₃O₄S
Molecular Weight:629.78
Hs Code.:

Synonyms:(S)-ethyl 2-(1-(3-(1H-Indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylate

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Chemical Property of (S)-ethyl 2-(1-(3-(1H-Indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylate

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Technology Process of (S)-ethyl 2-(1-(3-(1H-Indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylate

There total 5 articles about (S)-ethyl 2-(1-(3-(1H-Indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 830-96-6
Indole-3-propionic acid

: 1489279-19-7
C₂₇H₂₆N₂O₃S

: 1489279-24-4
(S)-ethyl 2-(1-(3-(1H-Indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 2130-96-3,54784-43-9
O-benzyl-N-tert-butoxycarbonyl-L-tyrosine

: 1489279-24-4
(S)-ethyl 2-(1-(3-(1H-Indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 2 h / 20 °C

2: Lawessons reagent / tetrahydrofuran / 2 h / 65 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 20 °C

With Lawessons reagent; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2013.09.017

Reference yield:

: 95271-93-5
benzoylaminoacetic acid ethyl ester

: 1489279-24-4
(S)-ethyl 2-(1-(3-(1H-Indol-3-yl)propanamido)-2-(4-(benzyloxy)phenyl)ethyl)-5-phenylthiazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 2 h / 20 °C

2: Lawessons reagent / tetrahydrofuran / 2 h / 65 °C

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap; triethylamine / dichloromethane / 20 °C

With Lawessons reagent; dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2013.09.017